Synthesis, Crystal Structure, and Biological Activity of Ethyl 4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate Polymorphic Forms
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DOI: 10.3390/scipharm86020021
Abstract: Continuing the search for new potential analgesics among the derivatives of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, the possibility of obtaining its esters by the alkylation of the corresponding sodium salt with iodoethane in dimethyl sulfoxide (DMSO) at room… read more here.
Keywords: ethyl methyl; methyl dioxo; dioxo benzothiazine; benzothiazine carboxylate ... See more keywords
Crystal Habits and Biological Properties of N-(4-Trifluoromethylphenyl)-4-Hydroxy-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxamide
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DOI: 10.3390/scipharm88010001
Abstract: In order to study polymorphic modifications of N-(4-trifluoromethylphenyl)-4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide, which is of interest as a promising analgesic, its three colorless crystal forms with different habitus have been obtained: sticks of ethyl acetate, plates of meta-xylene and… read more here.
Keywords: benzothiazine carboxamide; hydroxy dioxo; dioxo benzothiazine; trifluoromethylphenyl hydroxy ... See more keywords