Discovery and SAR analysis of phenylbenzo[d][1,3]dioxole-based proprotein convertase subtilisin/kexin type 9 inhibitors
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DOI: 10.1080/14756366.2022.2101645
Abstract: Abstract Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a novel therapeutic target for the development of cholesterol-lowering drugs. In the discovery of PCSK9/LDLR (low-density lipoprotein receptor) protein-protein interaction (PPI) impairing small molecules, a… read more here.
Keywords: phenylbenzo dioxole; dioxole based; subtilisin kexin; proprotein convertase ... See more keywords