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Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100107
Abstract: Indoleamine 2,3‐dioxygenase 1 (IDO1) is a promising therapeutic target in cancer immunotherapy and neurological disease. Thus, searching for highly active inhibitors for use in human cancers is now a focus of widespread research and development…
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Keywords:
brain penetrant;
dioxygenase ido1;
ido1 inhibitors;
indoleamine dioxygenase ... See more keywords
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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.12.029
Abstract: High expression of the immunosuppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1) for a broad range of malignancies is associated with poor patient prognosis, and the enzyme is a validated target for cancer intervention. To identify novel…
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Keywords:
ido1;
enzyme indoleamine;
dioxygenase ido1;
ido1 inhibitors ... See more keywords
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1
Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.03.012
Abstract: ABSTRACT Indoleamine 2,3‐dioxygenase 1 (IDO1) plays a key role in the immune system by regulating tryptophan levels and T cell differentiation. Several tumor types overexpress IDO1 to avoid immune surveillance making IDO1 of interest as…
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Keywords:
ido1;
aryl hydrocarbon;
indoleamine dioxygenase;
ido1 inhibitors ... See more keywords
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1
Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01665
Abstract: Since the discovery of the implication of indoleamine 2,3-dioxygenase 1 (IDO1) in tumoral immune resistance in 2003, the search for inhibitors has been intensely pursued both in academia and in pharmaceutical companies, supported by the…
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Keywords:
indoleamine dioxygenase;
dioxygenase ido1;
ido1;
ido1 structure ... See more keywords
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1
Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2089665
Abstract: Abstract The haem enzyme indoleamine 2,3-dioxygenase 1 (IDO1) catalyses the rate-limiting step in the kynurenine pathway of tryptophan metabolism and plays an essential role in immunity, neuronal function, and ageing. Expression of IDO1 in cancer…
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Keywords:
indoleamine dioxygenase;
based optimization;
ido1 inhibitors;
dioxygenase ido1 ... See more keywords
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Published in 2019 at "Molecules"
DOI: 10.3390/molecules24234346
Abstract: Cancers express tryptophan catabolising enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) to produce immunosuppressive tryptophan metabolites that undermine patients’ immune systems, leading to poor disease outcomes. Both enzymes are validated targets for cancer…
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Keywords:
ido1;
tdo2;
dioxygenase ido1;
indoleamine dioxygenase ... See more keywords