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   Articles with "dipeptide" as a keyword



Structural Characterization of Chirality‐Organized Ferrocene–Dipeptide Conjugates that Contain Pyridine N‐Oxide Moieties

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recommendations! Published in 2017 at "Asian Journal of Organic Chemistry"

DOI: 10.1002/ajoc.201700145

Abstract: Two ferrocene–dipeptide conjugates, Fc(l-Ala−l-Pro−PyO)2 (2) and Fc(l-Ala−l-Pro−PyO)1 (3), were synthesized by the introduction of an l-Ala−l-Pro dipeptide that contained a C-terminal pyridine N-oxide moiety into the ferrocene organometallic scaffold. Single-crystal X-ray structure determination of ferrocene–dipeptide… read more here.

Keywords: dipeptide; pyridine oxide; dipeptide conjugates; chirality organized ... See more keywords

Biotechnological production of the angiotensin‐converting enzyme inhibitory dipeptide isoleucine‐tryptophan

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recommendations! Published in 2018 at "Engineering in Life Sciences"

DOI: 10.1002/elsc.201700172

Abstract: Peptides with angiotensin‐converting enzyme (ACE)‐inhibitory and antihypertensive effects are suggested as innovative food additives to prevent or treat hypertension. Currently, these substances are isolated from food proteins following nonselective hydrolysis as a mixture of ACE‐inhibitory… read more here.

Keywords: dipeptide isoleucine; dipeptide; isoleucine tryptophan; ace inhibitory ... See more keywords

Synthesis of novel dipeptide sulfonamide conjugates with effective carbonic anhydrase I, II, IX, and XII inhibitory properties.

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recommendations! Published in 2018 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2018.08.032

Abstract: Twenty-four novel sulfonamide derivatives incorporating dipeptide tails were synthesized by facile acylation reactions of homosulfanilamide through benzotriazole or dicyclohexyl carbodiimide (DCC) mediated coupling reactions. The carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activity of the new… read more here.

Keywords: carbonic anhydrase; dipeptide; inhibitory properties; xii ... See more keywords

Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense.

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recommendations! Published in 2022 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2022.114328

Abstract: In this paper, we developed a new series of dipeptide nitriles that were demonstrated to be reversible rhodesain inhibitors at nanomolar level, with EC50 values against cultured T. b. brucei in the micromolar range. We also… read more here.

Keywords: development novel; dipeptide nitriles; dipeptide; novel dipeptide ... See more keywords

Catalytic Enantiodivergent Michael Addition by Subtle Adjustment of Achiral Amino Moiety of Dipeptide Phosphines

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recommendations! Published in 2020 at "iScience"

DOI: 10.1016/j.isci.2020.101138

Abstract: Summary Over the past decades, asymmetric catalysis has been intensely investigated as a powerful tool for the preparation of numerous chiral biologically active compounds. However, developing general and practical strategies for preparation of both enantiomers… read more here.

Keywords: dipeptide; enantiodivergent michael; addition; catalytic enantiodivergent ... See more keywords

p38 mitogen-activated protein kinases (MAPKs) are involved in intestinal immune response to bacterial muramyl dipeptide challenge in Ctenopharyngodon idella.

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recommendations! Published in 2019 at "Molecular immunology"

DOI: 10.1016/j.molimm.2019.12.007

Abstract: The p38 mitogen-activated protein kinases (MAPKs) are essential cytoplasmic signal molecules of innate immune pathways that play a vital role in host immune defense responses to pathogenic challenges. In this study, two fish p38 genes… read more here.

Keywords: dipeptide; cip38; p38 mitogen; p38 ... See more keywords

Vibrational and structural properties of L-Alanyl-L-Phenylalanine dipeptide by Raman spectroscopy, infrared and DFT calculations

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recommendations! Published in 2018 at "Vibrational Spectroscopy"

DOI: 10.1016/j.vibspec.2018.08.001

Abstract: Abstract A study of vibrational and structural properties of l -Alanyl- l -Phenylalanine hydrophobic dipeptide (molecular formula C12H16N2O3) is reported. The l -alanyl- l -phenylalanine is formed by two hydrophobic amino acids, L-alanine and l… read more here.

Keywords: dipeptide; structural properties; properties alanyl; alanyl phenylalanine ... See more keywords

Supramolecular Dipeptide-Based Near-Infrared Fluorescent Nanotubes for Cellular Mitochondria Targeted Imaging and Early Apoptosis.

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recommendations! Published in 2021 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.1c00106

Abstract: Herein, we have designed and synthesized unsymmetrical visible Cy-3 and near-infrared (NIR) Cy-5 chromophores anchoring mitochondria targeting functional group conjugated with a Phe-Phe dipeptide by a microwave-assisted Fmoc solid phase peptide synthesis method on Wang… read more here.

Keywords: dipeptide; apoptosis; early apoptosis; near infrared ... See more keywords

Redox Sensitive Self-Assembling Dipeptide for Sustained Intracellular Drug Delivery.

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recommendations! Published in 2019 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.9b00532

Abstract: The rational design and synthesis of molecules with functional supramolecular assemblies continues to be a challenging endeavor. Self-assembled nano- and micro-structures from natural building blocks are considered more appropriate for medical applications due to their… read more here.

Keywords: dipeptide; drug delivery; redox; drug ... See more keywords

Adiponectin-Receptor Agonistic Dipeptide Tyr-Pro Stimulates the Acetylcholine Nervous System in NE-4C Cells.

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recommendations! Published in 2024 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.3c07821

Abstract: The dipeptide Tyr-Pro has physiological potential for intact transportability into the brain parenchyma, prevention of cognitive impairment, and an adiponectin receptor 1 (AdipoR1) agonistic effect. The present study aimed to understand the effect of Tyr-Pro… read more here.

Keywords: nervous system; adiponectin receptor; dipeptide tyr; dipeptide ... See more keywords

Optimizing lysosomal activation of antibody-drug conjugates (ADCs) by incorporation of novel cleavable dipeptide linkers.

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recommendations! Published in 2019 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.9b00696

Abstract: Although peptide linkers are used in multiple clinical-stage ADCs, there are only few reports on optimizing peptide linkers for efficient lysosomal proteolysis and for stability in circulation. We screened multiple dipeptide linkers for efficiency of… read more here.

Keywords: ala ala; dipeptide; linker; dipeptide linkers ... See more keywords