Optimizing lysosomal activation of antibody-drug conjugates (ADCs) by incorporation of novel cleavable dipeptide linkers.
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DOI: 10.1021/acs.molpharmaceut.9b00696
Abstract: Although peptide linkers are used in multiple clinical-stage ADCs, there are only few reports on optimizing peptide linkers for efficient lysosomal proteolysis and for stability in circulation. We screened multiple dipeptide linkers for efficiency of… read more here.
Keywords: ala ala; dipeptide; linker; dipeptide linkers ... See more keywords