Dipeptide Mimetic of the Brain-derived Neurotrophic Factor Prevents Impairments of Neurogenesis in Stressed Mice
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DOI: 10.1007/s10517-017-3638-9
Abstract: Brain-derived neurotrophic factor (BDNF) plays the central role in the mechanisms of regulation of neurogenesis and neuroplasticity. Impairment of these mechanisms is considered as one of the main etiological factors of depression. Dimeric dipeptide mimetic… read more here.
Keywords: brain derived; derived neurotrophic; gsb 106; stressed mice ... See more keywords
Antiangiogenic Effects of Nerve Growth Factor Loop 4 Monomeric Dipeptide Mimetic
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DOI: 10.1007/s10517-017-3735-9
Abstract: The effects of GK-1, a monomeric dipeptide mimetic of nerve growth factor (NGF) loop 4, on angiogenesis were studied in vitro and in vivo. Experiments on human umbilical vein endothelial cells HUVEC showed that the… read more here.
Keywords: nerve growth; growth factor; monomeric dipeptide; dipeptide mimetic ... See more keywords
A novel dimeric dipeptide mimetic of the BDNF selectively activates the MAPK-Erk signaling pathway
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DOI: 10.1134/s1607672917050027
Abstract: On the basis of the structure of beta-turn of loop 2 of brain-derived neurotrophic factor (BDNF), its new dimeric dipeptide mimetic bis-(N-hexanoyl-L-seryl-L-lysine) hexamethylenediamide (GTS-201) was created. It activated TrkB and Erk, did not activate Akt,… read more here.
Keywords: novel dimeric; dimeric dipeptide; erk; dipeptide mimetic ... See more keywords