Association of Glucagon-Like Peptide-1 Receptor Agonist vs Dipeptidyl Peptidase-4 Inhibitor Use With Mortality Among Patients With Type 2 Diabetes and Advanced Chronic Kidney Disease
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.1169
Abstract: This cohort study assesses whether treatment with glucagon-like peptide-1 (GLP-1) receptor agonists is associated with better outcomes than treatment with dipeptidyl peptidase-4 (DPP-4) inhibitors among patients with type 2 diabetes and advanced-stage chronic kidney disease… read more here.
Keywords: dipeptidyl peptidase; kidney; glucagon like; kidney disease ... See more keywords
Dipeptidyl Peptidase 4/Midline‐1 Axis Promotes T Lymphocyte Motility in Atherosclerosis
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204194
Abstract: T cells play a crucial role in atherosclerosis, with its infiltration preceding the formation of atheroma. However, how T‐cell infiltration is regulated in atherosclerosis remains largely unknown. Here, this work demonstrates that dipeptidyl peptidase‐4 (DPP4)… read more here.
Keywords: dipeptidyl peptidase; dpp4; motility; atherosclerosis ... See more keywords
A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl Peptidase and Fibroblast Activation Protein
Sign Up to like & getrecommendations! Published in 2020 at "Chemmedchem"
DOI: 10.1002/cmdc.202000591
Abstract: Drugs targeting type 4 dipeptidyl peptidase (DPP‐4) are beneficial for glycemic control, whereas fibroblast activation protein alpha (FAP‐α) is a potential target for cancer therapies. Unlike other gliptins, linagliptin displays FAP inhibition. We compared biophysical… read more here.
Keywords: amino; amino acid; type dipeptidyl; dipeptidyl peptidase ... See more keywords
Vildagliptin‐Derived Dipeptidyl Peptidase 9 (DPP9) Inhibitors: Identification of a DPP8/9‐Specific Lead
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200097
Abstract: Vildagliptin is a marketed DPP4 inhibitor, used in the management of type 2 diabetes. The molecule also has notable DPP8/9 affinity, with some preference for DPP9. Therefore, we aimed to use vildagliptin as a starting… read more here.
Keywords: dpp8; vildagliptin; dipeptidyl peptidase; derived dipeptidyl ... See more keywords
Safety, Pharmacokinetics, and Pharmacodynamics of a Dipeptidyl Peptidase‐4 Inhibitor: A Randomized, Double‐Blinded, Placebo‐Controlled Daily Administration of Fotagliptin Benzoate for 14 Days for Type 2 Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.895
Abstract: This study investigated the pharmacokinetics, pharmacodynamics, and safety of fotagliptin benzoate (fotagliptin), a dipeptidyl peptidase‐4 (DPP‐4) inhibitor, in Chinese patients with type 2 diabetes mellitus (T2DM). In a randomized, double‐blinded, placebo‐controlled study, 10 and 4… read more here.
Keywords: fotagliptin; dipeptidyl peptidase; type diabetes; pharmacokinetics pharmacodynamics ... See more keywords
Adding vitamin D3 to the dipeptidyl peptidase‐4 inhibitor saxagliptin has the potential to protect β‐cell function in LADA patients: A 1‐year pilot study
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3298
Abstract: This trial was conducted to explore the protective effect on β‐cell function of adding vitamin D3 to DPP‐4 inhibitors to treat patients with latent autoimmune diabetes in adults (LADA). read more here.
Keywords: dipeptidyl peptidase; vitamin dipeptidyl; adding vitamin; cell function ... See more keywords
Effect of dipeptidyl peptidase‐4 inhibitors on complement activation
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3385
Abstract: Adverse activation of the complement cascade in the innate immune system appears to be involved in development of vascular complications in diabetes. Dipeptidyl peptidase‐4 (DPP‐4) is a cell surface serine protease expressed in a variety… read more here.
Keywords: peptidase inhibitors; effect dipeptidyl; activation; dipeptidyl peptidase ... See more keywords
Dipeptidyl peptidase 3, a biomarker in cardiogenic shock and hopefully much more
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1649
Abstract: Cardiogenic shock is a low-cardiac output condition due to primary cardiac dysfunction, resulting in inadequate peripheral tissue oxygen delivery.1 Despite efforts to improve cardiogenic shock interventions, including mechanical circulatory support and reperfusion therapy for myocardial… read more here.
Keywords: dipeptidyl peptidase; cardiogenic shock; shock;
Protease activated‐receptor 2 is necessary for neutrophil chemorepulsion induced by trypsin, tryptase, or dipeptidyl peptidase IV
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a0717-308r
Abstract: Compared to neutrophil chemoattractants, relatively little is known about the mechanism neutrophils use to respond to chemorepellents. We previously found that the soluble extracellular protein dipeptidyl peptidase IV (DPPIV) is a neutrophil chemorepellent. In this… read more here.
Keywords: neutrophil chemorepulsion; dipeptidyl peptidase; chemorepulsion; receptor ... See more keywords
Potential disease biomarkers: dipeptidyl peptidase 4 and fibroblast activation protein
Sign Up to like & getrecommendations! Published in 2017 at "Protoplasma"
DOI: 10.1007/s00709-017-1129-5
Abstract: The importance of the dipeptidyl peptidase 4 (DPP4) gene family in regulating critical biochemical pathways continues to emerge. The two most well-studied members of the family, DPP4 and fibroblast activation protein (FAP), have been investigated… read more here.
Keywords: disease biomarkers; disease; potential disease; activation protein ... See more keywords
Enantioseparation of DPP-4 Inhibitors on Immobilized Crown Ether-Based Chiral Stationary Phase
Sign Up to like & getrecommendations! Published in 2018 at "Chromatographia"
DOI: 10.1007/s10337-018-3626-x
Abstract: A group of DPP-4 inhibitors such as alogliptin, linagliptin and saxagliptin were selected for enantioseparation for this study. Crown ether columns contain a chiral crown ether ring as a chiral selector is suitable for the… read more here.
Keywords: peptidase inhibitors; crown ether; dpp inhibitors; enantioseparation dpp ... See more keywords