Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation
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DOI: 10.1007/s00401-020-02142-w
Abstract: Diffuse midline gliomas (DMG) H3 K27M-mutant was introduced in the 2016 WHO Classification of Tumors of the Central Nervous System, unifying diffuse intrinsic pontine gliomas (DIPG) and gliomas from the thalamus and spinal cord harboring… read more here.
Keywords: diffuse; midline gliomas; gliomas; diffuse midline ... See more keywords
Diffuse Intrinsic Pontine Glioma: From Diagnosis to Next-Generation Clinical Trials
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DOI: 10.1007/s11940-019-0577-y
Abstract: This review of diffuse intrinsic pontine glioma (DIPG) provides clinical background, a systematic approach to diagnosis and initial care, and synthesizes historical, modern, and future directions for treatment. We present evidence supporting neurosurgical biopsy, early… read more here.
Keywords: diffuse intrinsic; glioma; intrinsic pontine; clinical trials ... See more keywords
Potent anti-tumor efficacy of palbociclib in treatment-naïve H3.3K27M-mutant diffuse intrinsic pontine glioma
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DOI: 10.1016/j.ebiom.2019.04.043
Abstract: Background Diffuse intrinsic pontine glioma (DIPG) is a rare and fatal pediatric brain cancer without cure. Seeking therapeutic strategies is still a major challenge in DIPG research. Previous study has shown that dysregulation of G1/S… read more here.
Keywords: diffuse intrinsic; treatment; intrinsic pontine; dipg ... See more keywords
DIPG-01. REIRRADIATION PRACTICES FOR DIFFUSE INTRINSIC PONTINE GLIOMA
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DOI: 10.1093/neuonc/noaa222.053
Abstract: Abstract INTRODUCTION Diffuse intrinsic pontine gliomas (DIPG) are a leading cause of brain tumor deaths in children. Current standard of care includes focal radiation therapy (RT). Despite clinical improvement in the majority of patients, the… read more here.
Keywords: diffuse intrinsic; reirradiation; intrinsic pontine; dipg ... See more keywords
DIPG-03. THERAPEUTIC TARGETING OF TRANSCRIPTIONAL ELONGATION IN DIFFUSE INTRINSIC PONTINE GLIOMA
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DOI: 10.1093/neuonc/noaa222.055
Abstract: Abstract Diffuse intrinsic pontine glioma (DIPG) is highly aggressive brain stem tumor and needed to develop novel therapeutic agents for the treatment. The super elongation complex (SEC) is essential for transcription elongation through release of… read more here.
Keywords: diffuse intrinsic; elongation; intrinsic pontine; dipg ... See more keywords
DIPG-12. TARGETING EPIGENETIC MODIFIERS TO INDUCE IMMUNE SIGNALING IN DIPG
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DOI: 10.1093/neuonc/noaa222.062
Abstract: Abstract DIPG is a universally fatal pediatric brainstem tumor with no effective therapy. Recent work has shown that over 80% of DIPG cases harbor the H3K27M mutation leading to global loss of the repressive H3K27… read more here.
Keywords: dipg targeting; targeting epigenetic; modifiers induce; induce immune ... See more keywords
DIPG-22. DISSECTING THE ONCOGENIC ROLE OF FOXR2 IN DIFFUSE INTRINSIC PONTINE GLIOMA
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DOI: 10.1093/neuonc/noaa222.072
Abstract: Abstract BACKGROUND Diffuse intrinsic pontine gliomas (DIPGs) pose particular challenges for treatment. We recently completed a genomic analysis of close to 200 DIPGs and high-grade gliomas. We identified that nearly 10% of all DIPGs have… read more here.
Keywords: dipg; diffuse intrinsic; foxr2; intrinsic pontine ... See more keywords
DIPG-42. TOWARD MULTIMODALITY THERAPY FOR DIPG/DMG: DEVELOPMENT AND INVESTIGATION OF CRANIOSPINAL IRRADIATION AND CONVECTION-ENHANCED DELIVERY PDX MODELS
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DOI: 10.1093/neuonc/noaa222.089
Abstract: Abstract BACKGROUND Diffuse intrinsic pontine glioma (DIPG) and diffuse midline glioma (DMG) are metastatic diseases, as demonstrated by early convection-enhanced delivery (CED) clinical trials in which prolonged local tumor control can sometimes be achieved, but… read more here.
Keywords: pdx models; delivery; convection enhanced; dipg ... See more keywords
DIPG-54. A NON-INVASIVE PROGNOSTIC CIRCULATING miRNAs SIGNATURE IN DIFFUSE INTRINSIC PONTINE GLIOMAS
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DOI: 10.1093/neuonc/noaa222.099
Abstract: Abstract Diffuse intrinsic pontine gliomas (DIPG) are the most common brainstem tumors of childhood and represent one of the most challenging paediatric tumours to treat. A non-randomized, open label phase II pilot study was conducted… read more here.
Keywords: diffuse intrinsic; intrinsic pontine; non invasive; signature ... See more keywords
DIPG-56. EXPLORATION OF TUMOR/STROMA INTERACTIONS IN DIPG XENOGRAFT BY SPECIES-SPECIFIC RNA-SEQ DECONVOLUTION INDICATES A ROLE OF MICROGLIA CELL IN DIPG DEVELOPMENT
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DOI: 10.1093/neuonc/noaa222.101
Abstract: Abstract Diffuse Intrinsic Pontine Glioma (DIPG) and more largely Diffuse Midline Gliomas H3 K27M-mutant (DMG) harbor a unique property of infiltration. Our objective is to elucidate/describe the cellular and molecular determinants of micro-environmental modifications resulting… read more here.
Keywords: dipg xenograft; stroma; dipg; rna seq ... See more keywords
DIPG-84. COMPLEMENTARY AND ALTERNATIVE MEDICINE IN DIFFUSE INTRINSIC PONTINE GLIOMA
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DOI: 10.1093/neuonc/noaa222.125
Abstract: Abstract INTRODUCTION Diffuse intrinsic pontine glioma (DIPG) is a rare and aggressive childhood brainstem malignancy with a two-year survival rate of ≤10%. In this international survey study we aim to evaluate the use of complementary… read more here.
Keywords: diffuse intrinsic; medicine; cam; use ... See more keywords