Diphenhydramine, Sodium Bicarbonate, or Combination for Acute Peripheral Vertigo
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.41472
Abstract: Key Points Question Does intravenous sodium bicarbonate alone or with diphenhydramine provide better symptom relief than diphenhydramine alone for adults with acute peripheral vertigo? Findings In this randomized clinical trial of 225 patients, combination therapy… read more here.
Keywords: vertigo; diphenhydramine; acute peripheral; sodium ... See more keywords
Enhanced photodegradation of diphenhydramine in aqueous solution containing natural sand particles
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DOI: 10.1039/d0ra02019b
Abstract: Understanding the effects of natural solid particles on the phototransformation of pharmaceuticals in aqueous environments is very important, but studies on this are still limited. In this study, natural sands were selected as a solid… read more here.
Keywords: natural sand; photodegradation; diphenhydramine; sand particles ... See more keywords
Chitosan-coated alginate (CCA) nanoparticles for augmentation of topical antihistaminic activity of diphenhydramine: in-vitro optimization, skin histopathology and pharmacodynamic studies with in vitro/in vivo correlation.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development and industrial pharmacy"
DOI: 10.1080/03639045.2023.2211672
Abstract: OBJECTIVE The aim of the present study was to formulate chitosan-coated alginate nanoparticles containing the drug diphenhydramine hydrochloride (DHH). SIGNIFICANCE Diphenhydramine hydrochloride (DHH) is the prototype of H1-antihistaminic drugs. It is a lipophilic drug, that… read more here.
Keywords: chitosan coated; coated alginate; histopathology; diphenhydramine ... See more keywords
Elimination half-life of diphenhydramine in overdose
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Toxicology"
DOI: 10.1080/15563650.2017.1296153
Abstract: The features of diphenhydramine poisoning are well described [1]. Although the elimination half-life of diphenhydramine has been calculated after therapeutic dose [2–6], it has not been estimated in overdose. We report the clinical course, diphenhydramine… read more here.
Keywords: life diphenhydramine; diphenhydramine; elimination half; half life ... See more keywords
Postmortem diphenhydramine blood concentrations in children.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bkae084
Abstract: Diphenhydramine has been available for decades in non-prescription formulations for the treatment of allergic reactions, insomnia and symptomology associated with colds. In addition, dimenhydrinate, a precursor to diphenhydramine, is available in preparations for the treatment… read more here.
Keywords: concentrations children; diphenhydramine; blood concentrations; diphenhydramine blood ... See more keywords
Pharmacodynamic response profiles of anxiolytic and sedative drugs
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13204
Abstract: Aim Centrally‐acting acutely anxiolytic drugs, such as benzodiazepines, barbiturates and gabapentinoids, affect various central nervous system (CNS) functions, which reflects not only their anxiolytic effects but also neuropsychological side‐effects. To validate the pharmacodynamic biomarkers for… read more here.
Keywords: pregabalin diphenhydramine; anxiolytic sedative; diphenhydramine; study ... See more keywords
Donepezil: an unusual therapy for acute diphenhydramine overdose
Sign Up to like & getrecommendations! Published in 2019 at "BMJ Case Reports"
DOI: 10.1136/bcr-2018-226836
Abstract: An elderly man presented with the history of diphenhydramine hydrochloride overdose as a suicidal attempt. At presentation, he was in an acute confusional state with several anticholinergic features and had to be managed in intensive… read more here.
Keywords: acute diphenhydramine; therapy acute; diphenhydramine; unusual therapy ... See more keywords
Integrated biomarker response in signal crayfish Pacifastacus leniusculus exposed to diphenhydramine.
Sign Up to like & getrecommendations! Published in 2022 at "Chemosphere"
DOI: 10.2139/ssrn.4176680
Abstract: Diphenhydramine (DPH) is a pharmaceutical with multiple modes of action, primarily designed as an antihistamine therapeutic drug. Among antihistamines, DPH is a significant contaminant in the environment, frequently detected in surface waters, sediments, and tissues… read more here.
Keywords: pacifastacus leniusculus; biomarker response; integrated biomarker; crayfish pacifastacus ... See more keywords
Intramuscular Diphenhydramine Does Not Affect Acute Doxorubicin Infusion-Related Arrhythmia Number or Severity in a Prospective Crossover Study in Canine Lymphoma: A Pilot Study
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2020.00368
Abstract: Background: Doxorubicin (DOX) is one of the most effective chemotherapeutics for canine high-grade lymphoma. In addition to dose-dependent chronic cardiotoxicity, DOX can trigger acute cardiac arrhythmias during drug infusion. Diphenhydramine premedication is commonly used, as… read more here.
Keywords: lymphoma; infusion; diphenhydramine; study ... See more keywords
Ultrasound and Microwave-Assisted Synthesis and Antidiabetic and Hematopoietic Activity of Diphenhydramine Derivatives
Sign Up to like & getrecommendations! Published in 2025 at "Molecules"
DOI: 10.3390/molecules30142967
Abstract: This study presents the synthesis and antidiabetic and hematopoietic activity of ionic compounds based on 2-(diphenylmethoxy)-N,N-dimethylethanamine (diphenhydramine). Synthesis is carried out under ultrasonic (US) and microwave (MW) irradiation as well as using a conventional method… read more here.
Keywords: antidiabetic hematopoietic; diphenhydramine; synthesis antidiabetic; hematopoietic activity ... See more keywords
Cilia Stimulatory and Antibacterial Activities of T2R Bitter Taste Receptor Agonist Diphenhydramine: Insights into Repurposing Bitter Drugs for Nasal Infections
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15040452
Abstract: T2R bitter taste receptors in airway motile cilia increase ciliary beat frequency (CBF) and nitric oxide (NO) production. Polymorphisms in some T2Rs are linked to disease outcomes in chronic rhinosinusitis (CRS) and cystic fibrosis (CF).… read more here.
Keywords: agonist diphenhydramine; diphenhydramine; production; t2r bitter ... See more keywords