Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure-Activity Relationship.
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DOI: 10.1021/acs.jcim.3c00196
Abstract: Despite large investments from academia and industry, heart failure, which results from a disruption of the contractile apparatus, remains a leading cause of death. Cardiac muscle contraction is a calcium-dependent mechanism, which is regulated by… read more here.
Keywords: calcium; diphenyl moieties; small molecules; calcium sensitivity ... See more keywords