Salt formation of two BCS II drugs (indomethacin and naproxen) with (1R, 2R)-1,2-diphenylethylenediamine: Crystal structures, solubility and thermodynamics analysis
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DOI: 10.1016/j.molstruc.2019.02.104
Abstract: Abstract Indomethacin (Indo) and naproxen (Nap) belong to Biopharmaceutical Classification System (BCS) class II drugs, which permeate membranes well but are poorly soluble. Two pharmaceutical salts hydrate of Indo and Nap with (1R,2R)-1,2-diphenylethylenediamine (DPEN) were… read more here.
Keywords: solubility thermodynamics; diphenylethylenediamine; analysis; solubility ... See more keywords