Asymmetric Synthesis of Functionalized 9-Methyldecalins Using a Diphenylprolinol-Silyl-Ether-Mediated Domino Michael/Aldol Reaction.
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DOI: 10.1021/acs.orglett.1c02196
Abstract: Substituted 9-methyldecalin derivatives containing an all carbon quaternary chiral center were synthesized with excellent enantioselectivity via an organocatalyst-mediated domino reaction. The first reaction is a diphenylprolinol silyl ether-mediated Michael reaction, and the second reaction is… read more here.
Keywords: diphenylprolinol silyl; mediated domino; aldol reaction; silyl ether ... See more keywords