Synthesis of Phenoxyundecyl Diphosphate Disaccharides for Studies of the Biosynthesis of O Antigenic Polysaccharides in Enteric Bacteria.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9154-9_13
Abstract: The biosynthesis of O antigenic polysaccharides in enteric bacteria from nucleoside diphosphate sugars (donor substrates) is catalyzed by the corresponding glycosyltransferases and proceeds through the intermediate formation of undecaprenyl diphosphate sugars (acceptor substrates). To study… read more here.
Keywords: antigenic polysaccharides; biosynthesis antigenic; diphosphate; polysaccharides enteric ... See more keywords
Methylglyoxal augments uridine diphosphate-induced contraction via activation of p38 mitogen-activated protein kinase in rat carotid artery.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174155
Abstract: The methylglyoxal elicits diverse adverse effects on the body. Uridine diphosphate, an extracellular nucleotide, plays an important role as a signaling molecule controlling vascular tone. This study aimed to evaluate the relationship between methylglyoxal and… read more here.
Keywords: uridine diphosphate; induced contraction; methylglyoxal; diphosphate ... See more keywords
Characterization of 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (IspG) from Plasmodium vivax and it's potential as an antimalarial drug target.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2016.12.033
Abstract: The prokaryotic type Methyl Erythritol phosphate (MEP) pathway functional in the apicoplast of Plasmodium is indispensable for the erythrocytic stages of the parasite. It is the sole process of isoprenoids biosynthesis in the parasite and… read more here.
Keywords: methylbut diphosphate; hydroxy methylbut; target; diphosphate ... See more keywords
Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01878
Abstract: We report that alkyl-substituted bisphosphonates have activity against Bacillus anthracis Sterne (0.40 μg/mL), Mycobacterium smegmatis (1.4 μg/mL), Bacillus subtilis (1.0 μg/mL), and Staphylococcus aureus (13 μg/mL). In many cases, there is no effect of serum… read more here.
Keywords: cell wall; biosynthesis; diphosphate; quinone ... See more keywords
Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues
Sign Up to like & getrecommendations! Published in 2023 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.3c00047
Abstract: Thiamine is metabolized into the coenzyme thiamine diphosphate (ThDP). Interrupting thiamine utilization leads to disease states. Oxythiamine, a thiamine analogue, is metabolized into oxythiamine diphosphate (OxThDP), which inhibits ThDP-dependent enzymes. Oxythiamine has been used to… read more here.
Keywords: thiamine; thiamine diphosphate; dependent enzymes; thiamine utilization ... See more keywords
Mechanistic Studies of the Protonation-Deprotonation Reactions for Type 1 and Type 2 Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b07274
Abstract: Type 1 and type 2 isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IDI-1 and IDI-2) catalyze the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), the fundamental building blocks for biosynthesis of isoprenoid compounds. Previous studies indicate… read more here.
Keywords: type; isopentenyl diphosphate; dimethylallyl diphosphate; diphosphate ... See more keywords
A Cytosol-Localized Geranyl Diphosphate Synthase from Lithospermum erythrorhizon and Its Molecular Evolution1[OPEN]
Sign Up to like & getrecommendations! Published in 2020 at "Plant Physiology"
DOI: 10.1104/pp.19.00999
Abstract: A unique cytosol-localized geranyl diphosphate synthase supporting a large production of shikonin has evolved from farnesyl diphosphate synthase in Lithospermum erythrorhizon. Geranyl diphosphate (GPP) is the direct precursor of all monoterpenoids and is the prenyl… read more here.
Keywords: synthase; lithospermum erythrorhizon; geranyl diphosphate; diphosphate ... See more keywords
Genomic-Wide Identification and Characterization of the Uridine Diphosphate Glycosyltransferase Family in Eucommia ulmoides Oliver
Sign Up to like & getrecommendations! Published in 2021 at "Plants"
DOI: 10.3390/plants10091934
Abstract: Eucommia ulmoides Oliver is a woody plant with great economic and medicinal value. Its dried bark has a long history of use as a traditional medicinal material in East Asia, which led to many glycosides,… read more here.
Keywords: uridine diphosphate; eucommia ulmoides; genomic wide; diphosphate ... See more keywords