In‐silico structural characterization and phylogenetic analysis of Nucleoside diphosphate kinase: A novel antiapoptotic protein of Porphyromonas gingivalis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30389
Abstract: The Nucleoside diphosphate kinase (NDK) protein of Porphyromonas gingivalis (P. gingivalis) plays a crucial role in immune evasion and inhibition of apoptosis in host cells and has the potential to cause cancer. However, its structure… read more here.
Keywords: structure; gingivalis; nucleoside diphosphate; diphosphate kinase ... See more keywords
Genetic defects in peroxisome morphogenesis (Pex11β, dynamin‐like protein 1, and nucleoside diphosphate kinase 3) affect docosahexaenoic acid‐phospholipid metabolism
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DOI: 10.1002/jimd.12582
Abstract: Peroxisomes are essential organelles involved in lipid metabolisms including plasmalogen biosynthesis and β‐oxidation of very long‐chain fatty acids. Peroxisomes proliferate by the growth and division of pre‐existing peroxisomes. The peroxisomal membrane is elongated by Pex11β… read more here.
Keywords: docosahexaenoic acid; pex11; nucleoside diphosphate; acid ... See more keywords
The mitochondrial nucleoside diphosphate kinase (NDPK-D/NME4), a moonlighting protein for cell homeostasis
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DOI: 10.1038/s41374-017-0004-5
Abstract: Mitochondrial nucleoside diphosphate kinase (NDPK-D; synonyms: NME4, NM23-H4) represents the major mitochondrial NDP kinase. The homohexameric complex emerged as a protein with multiple functions in bioenergetics and phospholipid signaling. It occurs at different but precise… read more here.
Keywords: kinase ndpk; nucleoside diphosphate; diphosphate kinase; kinase ... See more keywords
Systematic gene silencing identified Cryptosporidium nucleoside diphosphate kinase and other molecules as targets for suppression of parasite proliferation in human intestinal cells
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DOI: 10.1038/s41598-019-48544-z
Abstract: Cryptosporidiosis is a major cause of diarrheal disease. The only drug approved for cryptosporidiosis has limited efficacy in high-risk populations. Therefore novel drugs are urgently needed. We have identified several enzymes as potential targets for… read more here.
Keywords: nucleoside diphosphate; diphosphate kinase; proliferation; cryptosporidium ... See more keywords
Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NFκB Activation
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DOI: 10.1158/1541-7786.mcr-17-0603
Abstract: Bacterial flagellin is a potent activator of NFκB signaling, inflammation, and host innate immunity, and recent data indicate that flagellin represents a novel antitumor ligand acting through toll-like receptor 5 (TLR5) and the NFκB pathway… read more here.
Keywords: nucleoside diphosphate; diphosphate kinase; kinase; tlr5 induced ... See more keywords
On-Flow Ligand Screening Assay Based on Immobilized Nucleoside Diphosphate Kinase b from Homo sapiens
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Brazilian Chemical Society"
DOI: 10.21577/0103-5053.20190133
Abstract: We describe an on-flow zonal affinity-based chromatography assay to screen ligands for the nucleoside diphosphate kinase B enzyme (NME2) from Homo sapiens. For the first time, we have covalently immobilized NME2 on the surface of… read more here.
Keywords: homo sapiens; diphosphate kinase; ligand screening; nucleoside diphosphate ... See more keywords
A Computational Approach for Understanding the Interactions between Graphene Oxide and Nucleoside Diphosphate Kinase with Implications for Heart Failure
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DOI: 10.3390/nano8020057
Abstract: During a heart failure, an increased content and activity of nucleoside diphosphate kinase (NDPK) in the sarcolemmal membrane is responsible for suppressing the formation of the second messenger cyclic adenosine monophosphate (cAMP)—a key component required… read more here.
Keywords: heart; computational approach; nucleoside diphosphate; diphosphate kinase ... See more keywords