Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy‐mediated drug resistance in ovarian cancer cells, xenografts, and patient‐derived xenograft models
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DOI: 10.1002/cncr.32600
Abstract: Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors exhibit promising activity against ovarian cancers, but their efficacy can be limited by acquired drug resistance. This study explores the role of autophagy in regulating the sensitivity of ovarian… read more here.
Keywords: drug resistance; adenosine diphosphate; poly adenosine; ribose polymerase ... See more keywords
Adenosine diphosphate ribose cyclase: An important regulator of human pathological and physiological processes
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DOI: 10.1002/jcp.30688
Abstract: Adenosine diphosphate ribose cyclase (ADPRC) exists widely in eukaryotes and lower metazoans cells. It can degrade nicotinamide adenine dinucleotide (NAD) into cyclic ADP ribose (cADPR) and nicotinamide, and subsequently hydrolyses cADPR to ADP ribose (ADPR).… read more here.
Keywords: adenosine diphosphate; cyclase important; diphosphate ribose; ribose cyclase ... See more keywords