Optimization of thermophilic trans‐isoprenyl diphosphate synthase expression in Escherichia coli by response surface methodology
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1459
Abstract: We optimized the heterologous expression of trans‐isoprenyl diphosphate synthase (IDS), the key enzyme involved in the biosynthesis of trans‐polyisoprene. trans‐Polyisoprene is a particularly valuable compound due to its superior stiffness, excellent insulation, and low thermal… read more here.
Keywords: methodology; isoprenyl diphosphate; response surface; expression ... See more keywords
Aclonifen targets the solanesyl diphosphate synthase, representing a novel mode of action for herbicides.
Sign Up to like & getrecommendations! Published in 2020 at "Pest management science"
DOI: 10.1002/ps.5781
Abstract: BACKGROUND Aclonifen is a unique diphenyl ether herbicide. Despite its structural similarities to known inhibitors of the protoporphyrinogen oxidase (e.g., acifluorfen, bifenox or oxadiazon), which result in leaf necrosis, aclonifen causes a different phenotype that… read more here.
Keywords: representing novel; solanesyl diphosphate; mode action; diphosphate synthase ... See more keywords
Characterization of 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (IspG) from Plasmodium vivax and it's potential as an antimalarial drug target.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2016.12.033
Abstract: The prokaryotic type Methyl Erythritol phosphate (MEP) pathway functional in the apicoplast of Plasmodium is indispensable for the erythrocytic stages of the parasite. It is the sole process of isoprenoids biosynthesis in the parasite and… read more here.
Keywords: methylbut diphosphate; hydroxy methylbut; target; diphosphate ... See more keywords
A Cytosol-Localized Geranyl Diphosphate Synthase from Lithospermum erythrorhizon and Its Molecular Evolution1[OPEN]
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DOI: 10.1104/pp.19.00999
Abstract: A unique cytosol-localized geranyl diphosphate synthase supporting a large production of shikonin has evolved from farnesyl diphosphate synthase in Lithospermum erythrorhizon. Geranyl diphosphate (GPP) is the direct precursor of all monoterpenoids and is the prenyl… read more here.
Keywords: synthase; lithospermum erythrorhizon; geranyl diphosphate; diphosphate ... See more keywords
Isoprenoid Amide Bisphosphonates As a Novel Class of Geranylgeranyl Diphosphate Synthase Inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-112965
Abstract: Multiple myeloma is characterized by the production of monoclonal protein by clonal plasma cells and is a malignancy inherently susceptible to agents that disrupt protein homeostasis. We have previously demonstrated that targeting the geranylgeranylation of… read more here.
Keywords: length; chain; stereochemistry; chain length ... See more keywords
Artemisia annua L. plants lacking Bornyl diPhosphate Synthase reallocate carbon from monoterpenes to sesquiterpenes except artemisinin
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1000819
Abstract: The monoterpene camphor is produced in glandular secretory trichomes of the medicinal plant Artemisia annua, which also produces the antimalarial drug artemisinin. We have found that, depending on growth conditions, camphor can accumulate at levels… read more here.
Keywords: camphor; artemisia annua; artemisinin; bornyl diphosphate ... See more keywords
Functional characterization and transcriptional activity analysis of Dryopteris fragrans farnesyl diphosphate synthase genes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2023.1105240
Abstract: Farnesyl diphosphate synthase (FPS), a key enzyme of the terpene metabolic pathway, catalyzes the precursor of sesquiterpene compounds farnesyl diphosphate (FPP) synthesis, and plays an important role in regulating plant growth and development. Dryopteris fragrans… read more here.
Keywords: functional characterization; farnesyl diphosphate; transcriptional activity; activity ... See more keywords
Structural Characterization of Full-Length Human Dehydrodolichyl Diphosphate Synthase Using an Integrative Computational and Experimental Approach
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DOI: 10.3390/biom9110660
Abstract: Dehydrodolichyl diphosphate synthase (DHDDS) is the catalytic subunit of the heteromeric human cis-prenyltransferase complex, synthesizing the glycosyl carrier precursor for N-linked protein glycosylation. Consistent with the important role of N-glycosylation in protein biogenesis, DHDDS mutations… read more here.
Keywords: length; dehydrodolichyl diphosphate; full length; diphosphate synthase ... See more keywords