1,3-Dipolar Cycloaddition Reactions of Nitrile Oxides under "Non-Conventional" Conditions: Green Solvents, Irradiation, and Continuous Flow.
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DOI: 10.1002/cplu.202000448
Abstract: The 1,3-dipolar cycloaddition reactions (DCs) of nitrile oxides (NOs) to alkenes and alkynes are useful methods for the synthesis of 2-isoxazolines and isoxazoles respectively, which are important classes of heterocyclic compounds in organic and medicinal… read more here.
Keywords: cycloaddition reactions; chemistry; nitrile oxides; reactions nitrile ... See more keywords
The Kinetic Solvent Effect on 1,3-Dipolar Cycloaddition of 2,2,5,5-Tetramethyl-3-imidazoline-3-oxide-1-oxyl.
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DOI: 10.1002/cplu.202200119
Abstract: The use of 2,2,5,5-tetramethyl-3-imidazoline-3-oxide-1-oxyl (1) as a controlling agent in Nitroxide Mediated Polymerization allows for activation of alkoxyamine homolysis by 1,3-dipolar cycloaddition of a vinyl monomer [Edeleva et al. Chem. Commun. 2019, 55, 190-193]. Polymerization can… read more here.
Keywords: dipolar cycloaddition; imidazoline oxide; oxide oxyl; tetramethyl imidazoline ... See more keywords
Regioselective Synthesis of Mono‐ and Dispiropyrazoline Derivatives via 1,3‐dipolar Cycloaddition with Nitrilimines
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DOI: 10.1002/jhet.2684
Abstract: The 1,3-dipolar cycloaddition reaction of (E,E)-1,3-bis(arylidene)indan-2-one with diarylnitrilimines, generated in situ via dehydrohalogenation of the corresponding hydrazonoyl chlorides , affords predominantly monospiropyrazolines and as a mixture of diastereoisomers. Also dispiropyrazolines are formed in moderate yields.… read more here.
Keywords: cycloaddition; mono dispiropyrazoline; synthesis mono; dispiropyrazoline derivatives ... See more keywords
1,3-Dipolar cycloaddition of 1-substituted 3,3,3-trifluoropropenes to ethyl cyanocarboxylate N-oxide
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DOI: 10.1007/s10593-018-2236-8
Abstract: 3,3,3-Trifluoropropene derivatives containing a sulfonyl, sulfoximine, or sulfamide substituent at position 1 were used in 1,3-dipolar cycloaddition reaction with ethyl cyanocarboxylate N-oxide generated by thermal decomposition of ethyl oximinochloroacetate, resulting in the formation of isomeric… read more here.
Keywords: cycloaddition substituted; ethyl cyanocarboxylate; cyanocarboxylate oxide; dipolar cycloaddition ... See more keywords
Synthesis of benzosuberone-tethered spirooxindoles: 1-3-dipolar cycloaddition of azomethine ylides and arylidene benzosuberones
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DOI: 10.1007/s11030-018-9901-9
Abstract: Expedient synthesis of benzosuberone-tethered spirooxindoles was accomplished by a three-component 1,3-dipolar cycloaddition reaction between azomethine ylide (generated in situ) and arylidene benzosuberone. This protocol offers good yield and wide functional group tolerance under mild reaction… read more here.
Keywords: benzosuberone tethered; tethered spirooxindoles; benzosuberone; synthesis benzosuberone ... See more keywords
Direct oxidation of Δ2-isoxazolines synthesis by metal ion-mediated diastereoface-selective 1,3-dipolar cycloaddition with “activated” DMSO
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DOI: 10.1016/j.arabjc.2012.12.008
Abstract: Abstract A series of 4-hydroxyl-Δ 2 -isoxazol-6(6a H )-one derivatives was prepared by magnesium ion-mediated diastereoface-selective 1,3-dipolar cycloaddition of aromatic nitrile oxides with pyrrolidinone derivatives. The reaction of 4-hydroxyl-Δ 2 -isoxazol-6(6a H )-one derivatives with… read more here.
Keywords: mediated diastereoface; diastereoface selective; selective dipolar; ion mediated ... See more keywords
Regio- and stereoselective synthesis of new spiro-isoxazolidines via 1,3-dipolar cycloaddition
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DOI: 10.1016/j.arabjc.2014.05.028
Abstract: Abstract New spiro-isoquinolinediones were prepared by regio- and stereoselective 1,3-dipolar cycloaddition of ( E )-4-arylidene- N -methyl-isoquinoline-1,3-dione derivatives 1a – d with C -aryl- N -phenylnitrones 2e – g . NMR studies confirmed that only… read more here.
Keywords: stereoselective synthesis; dipolar cycloaddition; new spiro; regio stereoselective ... See more keywords
1,3-Dipolar cycloaddition reaction for diastereoselective synthesis of functionalized dihydrospiro[indoline-3,2′-pyrroles]
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DOI: 10.1016/j.cclet.2016.07.016
Abstract: Abstract The BF3OEt2 catalyzed one-pot 1,3-dipolar cycloaddition reaction of benzylamines, isatins and dimethyl acetylenedicarboxylate in dry methylene dichloride afforded the functionalized dihydrospiro[indoline-3,2′-pyrroles] in moderate to good yields and with high diastereoselectivity. The reaction was accomplished… read more here.
Keywords: cycloaddition; cycloaddition reaction; dihydrospiro indoline; reaction ... See more keywords
A DFT mechanistic study of the generation of azomethine ylides from the ring-opening reactions of stabilized aziridines and follow-up 1,3-dipolar cycloaddition reactions with acetaldehyde
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DOI: 10.1016/j.comptc.2018.10.002
Abstract: Abstract This work investigated computationally with density functional theory calculations at the M06/6-311G∗ level, the ring opening reaction of various methyl-, phenyl- and carbonyl- substituted aziridines to obtain azomethine ylides and the subsequent 1,3-dipolar cycloaddition… read more here.
Keywords: kcal mol; ring opening; dipolar cycloaddition; azomethine ylides ... See more keywords
Synthesis of novel 1H-tetrazole derivatives of chitosan via metal-catalyzed 1,3-dipolar cycloaddition. Catalytic and antibacterial properties of [3-(1H-tetrazole-5-yl)ethyl]chitosan and its nanoparticles.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.03.153
Abstract: New tetrazole derivatives of chitosan with low, moderate, and high degrees of substitution were obtained using a novel approach, i.e. metal-catalyzed 1,3-dipolar cycloaddition of azide ion to cyanoethyl chitosan in water - the most straightforward,… read more here.
Keywords: tetrazole derivatives; derivatives chitosan; dipolar cycloaddition; metal catalyzed ... See more keywords
Kinetic Resolution of Alkylidene Norcamphors via a Ligand-Controlled Umpolung-Type 1,3-Dipolar Cycloaddition
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DOI: 10.1016/j.isci.2018.12.010
Abstract: Summary Development of a general catalytic and highly efficient method utilizing readily available precursors for the regio- and stereoselective construction of bioactive natural-product-inspired spiro architectures remains a formidable challenge in chemical research. Transition metal-catalyzed asymmetric… read more here.
Keywords: ligand controlled; cycloaddition; dipolar cycloaddition; kinetic resolution ... See more keywords