Combination Therapy with Dipyridamole and Clopidogrel for Secondary Stroke Prevention in Aspirin-Intolerant Patients After Myocardial Infarction: Results of a Nationwide Case-Control Study
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DOI: 10.1007/s40263-018-0591-8
Abstract: Background and PurposeCombination therapy with dipyridamole and clopidogrel in stroke prevention and long-term outcomes in aspirin-intolerant patients with acute myocardial infarction (AMI) and previous stroke are unknown. This nationwide study analyzed the impact of dipyridamole… read more here.
Keywords: clopidogrel; aspirin intolerant; myocardial infarction; dipyridamole clopidogrel ... See more keywords
Changes of electrocardiogram and hemodynamics in response to dipyridamole: In vivo comparative analyses using anesthetized beagle dogs and microminipigs.
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DOI: 10.1016/j.jphs.2018.01.002
Abstract: Microminipigs are expected as a novel animal model for cardiovascular pharmacological experiments. Since inherent vulnerability of coronary circulation of microminipigs has not been characterized, we performed dipyridamole-stress test to both microminipigs and beagle dogs, and… read more here.
Keywords: electrocardiogram hemodynamics; changes electrocardiogram; hemodynamics response; beagle dogs ... See more keywords
Utilization of Gastrointestinal Simulator, an in Vivo Predictive Dissolution Methodology, Coupled with Computational Approach To Forecast Oral Absorption of Dipyridamole.
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DOI: 10.1021/acs.molpharmaceut.6b01063
Abstract: Weakly basic drugs exhibit a pH-dependent dissolution profile in the gastrointestinal (GI) tract, which makes it difficult to predict their oral absorption profile. The aim of this study was to investigate the utility of the… read more here.
Keywords: methodology; vivo; gastrointestinal simulator; oral absorption ... See more keywords
0796 Dipyridamole for the Treatment of RLS: Preliminary Results of a Cross-Over, Placebo-Controlled, Double-Blind Trial
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DOI: 10.1093/sleep/zsaa056.792
Abstract: Recent animal models of restless legs syndrome (RLS) suggest that brain iron deficiency is associated with a hypoadenosinergic state, with downregulation of adenosine A1 receptors (A1R) in the striatum. Dipyridamole is a non-selective inhibitor of… read more here.
Keywords: treatment; dipyridamole; placebo; day ... See more keywords
Monitoring Platelet Function in Children With Ventricular Assist Devices: The Devil Is in the Details.
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DOI: 10.1097/mat.0000000000000948
Abstract: Ventricular assist device (VAD) implantation results in activation of the coagulation system and cellular components because of foreign biomaterials and shear stress generated by the pump.1 Antithrombotic therapy is given to mitigate this activation; however,… read more here.
Keywords: therapy; dipyridamole; antiplatelet; mea ... See more keywords
The signal pathway for the repressive effect of dipyridamole on myofibroblast transdifferentiation
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DOI: 10.1111/jcmm.14006
Abstract: Renal fibrosis is the common final pathway of various chronic kidney diseases (CKDs), irrespective of the initial causes of nephropathy. Decline of renal function, glomerular filtration rate, has been exhibited to be highly associated with… read more here.
Keywords: pathway; myofibroblast transdifferentiation; fibrosis; dipyridamole ... See more keywords
Dipyridamole ameliorates doxorubicin-induced cardiotoxicity
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DOI: 10.25122/jml-2021-0199
Abstract: Dipyridamole is a platelet inhibitor with antithrombotic properties that can help prevent stroke recurrence. Twenty-eight male rats were divided randomly into four groups (7 rats in each group). Control group: rats received a natural diet… read more here.
Keywords: induced cardiotoxicity; ameliorates doxorubicin; cardiotoxicity; group ... See more keywords
Early antithrombotic post-discharge therapy using prophylactic DOAC or dipyridamole improves long-term survival and cardiovascular outcomes in hospitalized COVID-19 survivors
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DOI: 10.3389/fcvm.2022.916156
Abstract: Introduction Cardiovascular events are common in COVID-19. While the use of anticoagulation during hospitalization has been established in current guidelines, recommendations regarding antithrombotic therapy in the post-discharge period are conflicting. Methods To investigate this issue,… read more here.
Keywords: doac; mortality; post discharge; dipyridamole ... See more keywords
Endoplasmic Reticulum Stress Contributed to Dipyridamole-Induced Impaired Autophagic Flux and Glioma Apoptosis
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DOI: 10.3390/ijms23020579
Abstract: Elevation of intracellular cAMP levels has been implicated in glioma cell proliferation inhibition, differentiation, and apoptosis. Inhibition of phosphodiesterase is a way to elevate intracellular cAMP levels. The present study aimed to investigate the anti-glioma… read more here.
Keywords: stress; apoptosis; impaired autophagic; autophagic flux ... See more keywords
Dipyridamole induces the phosphorylation of CREB to promote cancer cell proliferation
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DOI: 10.3892/ol.2021.12512
Abstract: Dipyridamole, a traditional anti-platelet drug, has been reported to inhibit the proliferation of cancer cells. The present study aimed to investigate the possibility of dipyridamole as an adjuvant of chemotherapy by enhancing the cytotoxicity of… read more here.
Keywords: creb promote; phosphorylation creb; induces phosphorylation; dipyridamole ... See more keywords
Formulation and Development of Gastroretentive Dipyridamole Microspheres: Proof of Concept by In vitro-In vivo Assessment
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DOI: 10.4172/pharmaceutical-sciences.1000343
Abstract: The present research was aimed at development and optimization of dipyridamole gastroretentive microspheres. Gastro retention was achieved using swellable polymeric material such as hydroxypropylmethylcellulose K4M, ethyl cellulose as release retardant using solvent diffusion evaporation method.… read more here.
Keywords: vitro vivo; dipyridamole; formulation; dipyridamole microspheres ... See more keywords