Identifying inducers of BDNF gene expression from pharmacologically validated compounds; antipyretic drug dipyrone increases BDNF mRNA in neurons.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.019
Abstract: Low levels of brain-derived neurotrophic factor (BDNF), a key regulator of synaptic plasticity, are associated with neurological diseases, including depression and Alzheimer's disease. Therefore, BDNF is a drug target for these diseases. Here we screened… read more here.
Keywords: dipyrone; drug; expression pharmacologically; expression ... See more keywords
Development of electroanalytical procedure for monitoring of metamizole in organic fertilizers (human urine and struvite) associated with portable equipment.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of environmental management"
DOI: 10.1016/j.jenvman.2020.110587
Abstract: Urine and struvite are promising organic fertilizers that can replace conventional fertilizers. However, these fertilizers can have some emerging contaminants, such as dipyrone. This drug is one of the main painkillers consumed in the world… read more here.
Keywords: human urine; urine struvite; dipyrone; organic fertilizers ... See more keywords
Development of a lateral flow immunoassay for the simultaneous detection of four dipyrone metabolites in milk
Sign Up to like & getrecommendations! Published in 2019 at "Analytical Methods"
DOI: 10.1039/c9ay00774a
Abstract: Dipyrone (DIP) is a commonly used non-steroidal anti-inflammatory drug with strong analgesic, antipyretic, and spasmolytic properties. read more here.
Keywords: dipyrone; immunoassay simultaneous; simultaneous detection; lateral flow ... See more keywords
Pharmacokinetics of dipyrone in horses: A multi-dose, dose escalation study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.12996
Abstract: Dipyrone is a non-opioid, nonsteroidal anti-inflammatory drug with antipyretic and analgesic properties commonly used in horses. Dipyrone is rapidly hydrolyzed to the primary active metabolite 4-methylaminoantipyrine (4-MAA). The purpose of this study was to determine… read more here.
Keywords: dipyrone horses; pharmacokinetics dipyrone; study; dipyrone ... See more keywords
Randomized blinded controlled trial of dipyrone as a treatment for pyrexia in horses.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of veterinary research"
DOI: 10.2460/ajvr.80.3.294
Abstract: OBJECTIVE To evaluate the effectiveness and safety of dipyrone to control pyrexia in horses with naturally occurring disease under field conditions. ANIMALS 138 horses with pyrexia and various infections evaluated at 14 veterinary sites in… read more here.
Keywords: treatment; pyrexia horses; dipyrone; rectal temperature ... See more keywords