Efficient construction of 5H-1,4-benzodiazepine derivatives by a catalyst-free direct aerobic oxidative annulation strategy.
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DOI: 10.1002/cssc.202100703
Abstract: A catalyst-free direct aerobic oxidative annulation reaction of 2-aminobenzylic amines and α- hydroxyl ketones can efficiently afford the versatile 5 H -1,4-benzodiazepine derivatives by employing air as the economic and green oxidant under mild conditions.… read more here.
Keywords: direct aerobic; free direct; oxidative annulation; benzodiazepine ... See more keywords
Direct Aerobic Generation of a Ferric Hydroperoxo Intermediate Via a Preorganized Secondary Coordination Sphere.
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DOI: 10.1021/jacs.1c06911
Abstract: Enzymes exert control over the reactivity of metal centers with precise tuning of the secondary coordination sphere of active sites. One particularly elegant illustration of this principle is in the controlled delivery of proton and… read more here.
Keywords: coordination sphere; direct aerobic; secondary coordination; hydroperoxo intermediate ... See more keywords