Tungsten-Catalyzed Direct N-Alkylation of Anilines with Alcohols.
Sign Up to like & getrecommendations! Published in 2020 at "ChemSusChem"
DOI: 10.1002/cssc.202002830
Abstract: The implementation of non-noble metals mediated chemistry is a major goal in homogeneous catalysis. Borrowing hydrogen/hydrogen autotransfer (BH/HA) reaction, as a straightforward and sustainable synthetic method, has attracted considerable attention in the development of non-noble… read more here.
Keywords: alkylation anilines; catalyzed direct; alkylation; anilines alcohols ... See more keywords
Direct α-C-H Alkylation of Structurally Diverse Alcohols via Combined Tavaborole and Photoredox Catalysis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03117
Abstract: Herein, we report a method that uses antifungal tavaborole as a co-catalyst for direct α-C-H alkylation of structurally diverse alcohols through photoredox catalysis. The protocol features mild conditions, remarkable scope, and wide functional group tolerance,… read more here.
Keywords: photoredox catalysis; alkylation structurally; direct alkylation; structurally diverse ... See more keywords
Direct Alkylation of 1-Azabicyclo[1.1.0]butanes.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00321
Abstract: The facile synthesis of functionalized azetidines has been an ongoing challenge. Here, we report a general method to directly alkylate 1-azabicyclo[1.1.0]butane (ABB) with organometal reagents in the presence of Cu(OTf)2 to rapidly prepare bis-functionalized azetidines.… read more here.
Keywords: alkylation azabicyclo; direct alkylation; azabicyclo butanes;
Direct β-Alkylation of Ketones and Aldehydes via Pd-Catalyzed Redox Cascade.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b03530
Abstract: We report a direct β-alkylation of ketones and aldehydes with simple alkyl bromides through a Pd-catalyzed redox-cascade strategy. The use of a Cu cocatalyst is important for improved efficiency. The reaction is redox-neutral, without the… read more here.
Keywords: ketones aldehydes; alkylation; catalyzed redox; redox cascade ... See more keywords
Direct N-alkylation of unprotected amino acids with alcohols
Sign Up to like & getrecommendations! Published in 2017 at "Science Advances"
DOI: 10.1126/sciadv.aao6494
Abstract: We present a method for N-alkylation of unprotected amino acids with alcohols with excellent yield and stereochemistry retention. N-alkyl amino acids find widespread application as highly valuable, renewable building blocks. However, traditional synthesis methodologies to… read more here.
Keywords: amino acids; alkylation unprotected; unprotected amino; acids alcohols ... See more keywords