LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "direct amidation" as a keyword



Montmorillonite‐K10‐Catalyzed Microwave‐Assisted Direct Amidation of Unactivated Carboxylic Acids with Amines: Maintaining Chiral Integrity of Substrates

Sign Up to like & get
recommendations! Published in 2017 at "Asian Journal of Organic Chemistry"

DOI: 10.1002/ajoc.201600590

Abstract: A microwave assisted, selective and green methodology has been developed for the direct amidation of carboxylic acids with amines using montmorillonite K10 as a heterogeneous catalyst. This is the first report for transition metal free,… read more here.

Keywords: acids amines; carboxylic acids; microwave assisted; direct amidation ... See more keywords

Unveiling the reaction process of the amine in direct amidation of aromatic ketones in H2O

Sign Up to like & get
recommendations! Published in 2020 at "ChemistryOpen"

DOI: 10.1002/open.202000178

Abstract: Abstract In the classical amidation between aromatic ketones and amines, 2.0 equivalents of amines are necessarily required to gain satisfying yields. The specific role of the amine in the direct amidation already puzzled us for… read more here.

Keywords: aromatic ketones; amine direct; direct amidation; amine ... See more keywords

Diastereoselective direct amidation/aza-Michael cascade reaction to synthesize cis-1,3-disubstituted isoindolines

Sign Up to like & get
recommendations! Published in 2020 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2020.152122

Abstract: Abstract A convenient and efficient base-promoted cascade reaction for the synthesis of cis-1,3-disubstituted isoindolines has been reported herein. We discovered that various N-protected imines bearing a Michael acceptor react smoothly with several nitrogenous nucleophiles in… read more here.

Keywords: cis disubstituted; michael; cascade reaction; disubstituted isoindolines ... See more keywords

Methyltrimethoxysilane (MTM) as a Reagent for Direct Amidation of Carboxylic Acids.

Sign Up to like & get
recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.1c04265

Abstract: Methyltrimethoxysilane [MTM, CH3Si(OMe)3] has been demonstrated to be an effective, inexpensive, and safe reagent for the direct amidation of carboxylic acids with amines. Two simple workup procedures that provide the pure amide product without the… read more here.

Keywords: reagent direct; direct amidation; carboxylic acids; amidation carboxylic ... See more keywords

Base-promoted direct amidation of esters: beyond the current scope and practical applications

Sign Up to like & get
recommendations! Published in 2022 at "RSC Advances"

DOI: 10.1039/d2ra03524c

Abstract: The base-promoted direct amidation of unactivated esters is among the most useful reactions for amide bond formation in contemporary organic chemistry. The intensive research in this area has led to the development of a number… read more here.

Keywords: promoted direct; base promoted; direct amidation; practical applications ... See more keywords

(o-CF3PhO)3P as a simple coupling reagent for direct amidation via activation of amines

Sign Up to like & get
recommendations! Published in 2024 at "Organic Chemistry Frontiers"

DOI: 10.1039/d3qo01705b

Abstract: An unprecedented procedure for direct amidation is reported that employs a stoichiometric amount of easy-to-access (o-CF3PhO)3P as a new and simple coupling agent. The developed reagent is proposed for the... read more here.

Keywords: direct amidation; reagent direct; cf3pho simple; simple coupling ... See more keywords

Substrate-directed novel direct amidation of resin-bound amino acids

Sign Up to like & get
recommendations! Published in 2024 at "Chemistry Letters"

DOI: 10.1093/chemle/upae107

Abstract: In peptide drug discovery, the C-terminal structure of peptide compounds is crucial for enhancing the affinity with target proteins and for optimizing the compound's dynamics and physical properties. In conventional solid-phase synthesis, two steps are… read more here.

Keywords: direct amidation; directed novel; novel direct; substrate directed ... See more keywords

Borane-Pyridine: An Efficient Catalyst for Direct Amidation

Sign Up to like & get
recommendations! Published in 2024 at "Molecules"

DOI: 10.3390/molecules29010268

Abstract: Borane-pyridine acts as an efficient (5 mol%) liquid catalyst, providing improved solubility for the direct amidation of a wide range of aromatic and aliphatic carboxylic acids and amines to form secondary and tertiary carboxamides. Tolerance… read more here.

Keywords: direct amidation; borane pyridine; pyridine efficient; efficient catalyst ... See more keywords