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Published in 2017 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201600590
Abstract: A microwave assisted, selective and green methodology has been developed for the direct amidation of carboxylic acids with amines using montmorillonite K10 as a heterogeneous catalyst. This is the first report for transition metal free,…
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Keywords:
acids amines;
carboxylic acids;
microwave assisted;
direct amidation ... See more keywords
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Published in 2020 at "ChemistryOpen"
DOI: 10.1002/open.202000178
Abstract: Abstract In the classical amidation between aromatic ketones and amines, 2.0 equivalents of amines are necessarily required to gain satisfying yields. The specific role of the amine in the direct amidation already puzzled us for…
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Keywords:
aromatic ketones;
amine direct;
direct amidation;
amine ... See more keywords
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Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152122
Abstract: Abstract A convenient and efficient base-promoted cascade reaction for the synthesis of cis-1,3-disubstituted isoindolines has been reported herein. We discovered that various N-protected imines bearing a Michael acceptor react smoothly with several nitrogenous nucleophiles in…
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Keywords:
cis disubstituted;
michael;
cascade reaction;
disubstituted isoindolines ... See more keywords
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Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04265
Abstract: Methyltrimethoxysilane [MTM, CH3Si(OMe)3] has been demonstrated to be an effective, inexpensive, and safe reagent for the direct amidation of carboxylic acids with amines. Two simple workup procedures that provide the pure amide product without the…
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Keywords:
reagent direct;
direct amidation;
carboxylic acids;
amidation carboxylic ... See more keywords
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Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra03524c
Abstract: The base-promoted direct amidation of unactivated esters is among the most useful reactions for amide bond formation in contemporary organic chemistry. The intensive research in this area has led to the development of a number…
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Keywords:
promoted direct;
base promoted;
direct amidation;
practical applications ... See more keywords