Borane-Catalyzed Direct Asymmetric Vinylogous Mannich Reactions of Acyclic α,β-Unsaturated Ketones.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c00006
Abstract: Herein, we report that, by using chiral bicyclic bisborane catalysts, we have achieved the first highly regio-, diastereo-, and enantioselective direct asymmetric vinylogous Mannich reactions of acyclic α,β-unsaturated ketones. The strong Lewis acidity and steric… read more here.
Keywords: acyclic unsaturated; direct asymmetric; asymmetric vinylogous; reactions acyclic ... See more keywords
Polyacrylic Acid Supported L-proline as an Effective Heterogeneous Catalyst for the Direct Asymmetric Aldol Reaction.
Sign Up to like & getrecommendations! Published in 2023 at "Current organic synthesis"
DOI: 10.2174/1570179420666230330085329
Abstract: INTRODUCTION L-proline is an efficient chiral small-molecule organocatalyst for the direct asymmetric aldol reaction between unmodified acetone and a variety of aldehydes. METHOD However, it is difficult to separate from the reaction medium for reuse.… read more here.
Keywords: catalyst; reaction; asymmetric aldol; aldol reaction ... See more keywords
Bioinspired Polymer-Bound Organocatalysts for Direct Asymmetric Aldol Reaction: Experimental and Computational Studies
Sign Up to like & getrecommendations! Published in 2019 at "Catalysts"
DOI: 10.3390/catal9050398
Abstract: A series of poly(2-oxazoline) (POX) derivatives bearing prolinamide pendants were designed as organocatalysts and evaluated in the direct asymmetric aldol reaction between aromatic aldehydes and cyclic ketones. The structural variation of the alkyl spacer connecting… read more here.
Keywords: aldol reaction; bound; aldol; reaction ... See more keywords