LAUSR

Control of RNA polymerase II-transcribed genes by direct binding of TOR kinase

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1 Published in 2017 at "Current Genetics"

DOI: 10.1007/s00294-017-0738-z

Abstract: Under conditions of nutrient limitation and cellular stress, or by addition of rapamycin, the mechanistic target of rapamycin complex 1 (mTORC1) is inhibited. This results in downregulation of genes that encode rRNA and ribosomal proteins.… read more here.

Keywords: polymerase transcribed; tor kinase; direct binding; control ... See more keywords

Regulation of sinoatrial funny channels by cyclic nucleotides: From adrenaline and IK2 to direct binding of ligands to protein subunits.

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0 Published in 2021 at "Progress in biophysics and molecular biology"

DOI: 10.1016/j.pbiomolbio.2021.06.010

Abstract: The funny current, and the HCN channels that form it, are affected by the direct binding of cyclic nucleotides. Binding of these second messengers causes a depolarizing shift of the activation curve, which leads to… read more here.

Keywords: direct binding; regulation sinoatrial; sinoatrial funny; cyclic nucleotides ... See more keywords

A cell-penetrating antibody inhibits human RAD51 via direct binding

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0 Published in 2017 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkx871

Abstract: Abstract RAD51, a key factor in homology-directed repair (HDR), has long been considered an attractive target for cancer therapy, but few specific inhibitors have been found. A cell-penetrating, anti-DNA, lupus autoantibody, 3E10, was previously shown… read more here.

Keywords: direct binding; hdr; dna; cell penetrating ... See more keywords

Regulation of PD-L1 through direct binding of cholesterol to CRAC motifs

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2 Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.abq4722

Abstract: Cholesterol, an essential molecule for cell structure, function, and viability, plays crucial roles in the development, progression, and survival of cancer cells. Earlier studies have shown that cholesterol-lowering drugs can inhibit the high expression of… read more here.

Keywords: direct binding; crac motifs; regulation direct; cholesterol ... See more keywords

Human α-Defensin-6 Neutralizes Clostridioides difficile Toxins TcdA and TcdB by Direct Binding

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1 Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23094509

Abstract: Rising incidences and mortalities have drawn attention to Clostridioides difficile infections (CDIs) in recent years. The main virulence factors of this bacterium are the exotoxins TcdA and TcdB, which glucosylate Rho-GTPases and thereby inhibit Rho/actin-mediated… read more here.

Keywords: direct binding; defensin; clostridioides difficile; tcda tcdb ... See more keywords