Control of RNA polymerase II-transcribed genes by direct binding of TOR kinase
Sign Up to like & getrecommendations! Published in 2017 at "Current Genetics"
DOI: 10.1007/s00294-017-0738-z
Abstract: Under conditions of nutrient limitation and cellular stress, or by addition of rapamycin, the mechanistic target of rapamycin complex 1 (mTORC1) is inhibited. This results in downregulation of genes that encode rRNA and ribosomal proteins.… read more here.
Keywords: polymerase transcribed; tor kinase; direct binding; control ... See more keywords
Regulation of sinoatrial funny channels by cyclic nucleotides: From adrenaline and IK2 to direct binding of ligands to protein subunits.
Sign Up to like & getrecommendations! Published in 2021 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2021.06.010
Abstract: The funny current, and the HCN channels that form it, are affected by the direct binding of cyclic nucleotides. Binding of these second messengers causes a depolarizing shift of the activation curve, which leads to… read more here.
Keywords: direct binding; regulation sinoatrial; sinoatrial funny; cyclic nucleotides ... See more keywords
Direct binding to sterols accelerates endoplasmic reticulum-associated degradation of HMG CoA reductase
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2318822121
Abstract: Significance Endoplasmic reticulum-associated degradation (ERAD) of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase) plays a key role in the feedback regulation of cholesterol synthesis. This ERAD is stimulated by the cholesterol synthesis intermediate 24,25-dihydrolanosterol (DHL) and the… read more here.
Keywords: binding sterols; direct binding; endoplasmic reticulum; reticulum associated ... See more keywords
A cell-penetrating antibody inhibits human RAD51 via direct binding
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx871
Abstract: Abstract RAD51, a key factor in homology-directed repair (HDR), has long been considered an attractive target for cancer therapy, but few specific inhibitors have been found. A cell-penetrating, anti-DNA, lupus autoantibody, 3E10, was previously shown… read more here.
Keywords: direct binding; hdr; dna; cell penetrating ... See more keywords
Regulation of PD-L1 through direct binding of cholesterol to CRAC motifs
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq4722
Abstract: Cholesterol, an essential molecule for cell structure, function, and viability, plays crucial roles in the development, progression, and survival of cancer cells. Earlier studies have shown that cholesterol-lowering drugs can inhibit the high expression of… read more here.
Keywords: direct binding; crac motifs; regulation direct; cholesterol ... See more keywords
Emodin mitigates rheumatoid arthritis through direct binding to TNF-α
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1520281
Abstract: Emodin has shown certain anti-rheumatoid arthritis (RA) activity in preliminary studies. However, the precise mechanisms of emodin’s anti-RA effects, particularly its direct targets, remain unclear. This study aimed to evaluate the anti-RA activity of emodin… read more here.
Keywords: emodin; tnf; direct binding; rheumatoid arthritis ... See more keywords
Human α-Defensin-6 Neutralizes Clostridioides difficile Toxins TcdA and TcdB by Direct Binding
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094509
Abstract: Rising incidences and mortalities have drawn attention to Clostridioides difficile infections (CDIs) in recent years. The main virulence factors of this bacterium are the exotoxins TcdA and TcdB, which glucosylate Rho-GTPases and thereby inhibit Rho/actin-mediated… read more here.
Keywords: direct binding; defensin; clostridioides difficile; tcda tcdb ... See more keywords