Discovery and progress of direct cardiac reprogramming
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2466-4
Abstract: Cardiac disease remains a major cause of death worldwide. Direct cardiac reprogramming has emerged as a promising approach for cardiac regenerative therapy. After the discovery of MyoD, a master regulator for skeletal muscle, other single… read more here.
Keywords: direct cardiac; progress direct; cardiac reprogramming; cardiac ... See more keywords
Direct Reprogramming, Epigenetics, and Cardiac Regeneration.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of cardiac failure"
DOI: 10.1016/j.cardfail.2017.05.009
Abstract: The discovery of induced pluripotent stem cells (iPSCs) has revolutionized regenerative medicine. Autologous iPSCs can be generated by introducing 4 stem cell-specific factors (Oct4, Sox2, Klf4, c-Myc) into fibroblasts. iPSCs can propagate indefinitely and differentiate… read more here.
Keywords: medicine; cardiac regeneration; direct cardiac; cardiac reprogramming ... See more keywords
Boosters and barriers for direct cardiac reprogramming
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.04.013
Abstract: &NA; Heart disease is currently the most significant cause of morbidity and mortality worldwide, which accounts for approximately 33% of all deaths. Recently, a promising and alchemy‐like strategy has been developed called direct cardiac reprogramming,… read more here.
Keywords: efficiency direct; direct cardiac; boosters barriers; cardiac reprogramming ... See more keywords
Compliant Buckled Foam Actuators and Application in Patient-Specific Direct Cardiac Compression.
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DOI: 10.1089/soro.2017.0018
Abstract: We introduce the use of buckled foam for soft pneumatic actuators. A moderate amount of residual compressive strain within elastomer foam increases the applied force ∼1.4 × or stroke ∼2 × compared with actuators without residual strain.… read more here.
Keywords: compression; patient specific; direct cardiac; buckled foam ... See more keywords
Three-dimensional heart extracellular matrix enhances chemically induced direct cardiac reprogramming
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn5768
Abstract: Direct cardiac reprogramming has emerged as a promising therapeutic approach for cardiac regeneration. Full chemical reprogramming with small molecules to generate cardiomyocytes may be more amenable than genetic reprogramming for clinical applications as it avoids… read more here.
Keywords: heart extracellular; extracellular matrix; three dimensional; direct cardiac ... See more keywords