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   Articles with "direct compression" as a keyword



Lubricant based determination of design space for continuously manufactured high dose paracetamol tablets

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recommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ejps.2017.12.021

Abstract: Abstract The objective of this study was to devise robust and stable continuous manufacturing process settings, by exploring the design space after an investigation of the lubrication‐based parameters influencing the continuous direct compression tableting of… read more here.

Keywords: compression tableting; continuous direct; direct compression; design space ... See more keywords

Continuous direct compression as manufacturing platform for sustained release tablets.

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recommendations! Published in 2017 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2017.01.010

Abstract: This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging sustained release formulation with high content of a poorly flowing low density drug was selected. Two… read more here.

Keywords: methocel; continuous direct; direct compression; sustained release ... See more keywords

Self‐microemulsifying tablets prepared by direct compression for improved resveratrol delivery

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recommendations! Published in 2018 at "International Journal of Pharmaceutics"

DOI: 10.1016/j.ijpharm.2018.06.065

Abstract: ABSTRACT The purpose of this study was to develop self‐microemulsifying (SME‐) tablets to improve resveratrol solubility whilst delivering resveratrol in a preferred tablet dosage form. Resveratrol was dissolved in liquid self‐microemulsifying drug delivery system (SMEDDS)… read more here.

Keywords: resveratrol; self microemulsifying; direct compression; tablets prepared ... See more keywords

Comparison of fused‐filament fabrication to direct compression and injection molding in the manufacture of oral tablets

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recommendations! Published in 2019 at "International Journal of Pharmaceutics"

DOI: 10.1016/j.ijpharm.2019.01.013

Abstract: ABSTRACT Oral tablets are a convenient form to deliver active pharmaceutical ingredients (API) and have a high level of acceptance from clinicians and patients. There is a wide range of excipients available for the fabrication… read more here.

Keywords: compression injection; fused filament; direct compression; fabrication ... See more keywords
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Effect of binder type and lubrication method on the binder efficacy for direct compression.

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recommendations! Published in 2021 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2021.120968

Abstract: The effect of different binders for direct compression on tablet critical quality attributes was investigated. Dicalcium phosphate, lactose and microcrystalline cellulose were used as fillers and combined with ten binders (10, 20 and 30% w/w).… read more here.

Keywords: tensile strength; lubrication method; direct compression; effect ... See more keywords
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Tracking raw material flow through a continuous direct compression line Part I of II: Residence time distribution modeling and sensitivity analysis enabling increased process yield.

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recommendations! Published in 2022 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2022.121467

Abstract: Continuous manufacturing (CM) offers advantages in quality and space-time yield compared to common batch manufacturing. However, higher yield losses due to the start-up procedure make a broad application uneconomical. This work discusses the possibility of… read more here.

Keywords: time; yield; direct compression; sensitivity analysis ... See more keywords

Integrated modeling of a continuous direct compression tablet manufacturing process: A production scale case study

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recommendations! Published in 2019 at "Powder Technology"

DOI: 10.1016/j.powtec.2019.05.078

Abstract: Abstract A flowsheet model for a continuous direct compression tableting process is developed and applied to process data generated at production scale. The model contains powder feeding, blending and tablet compaction unit operations. The dataset… read more here.

Keywords: tablet; continuous direct; process; model ... See more keywords

Control Strategies for Drug Product Continuous Direct Compression-State of Control, Product Collection Strategies, and Startup/Shutdown Operations for the Production of Clinical Trial Materials and Commercial Products.

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recommendations! Published in 2017 at "Journal of pharmaceutical sciences"

DOI: 10.1016/j.xphs.2016.12.014

Abstract: Continuous manufacturing (CM) has emerged in the pharmaceutical industry as a paradigm shift with significant advantages related to cost, efficiency, flexibility, and higher assurance of quality. The inherent differences from batch processes justify examining the… read more here.

Keywords: control; state control; direct compression; product ... See more keywords

Novel bioequivalent oral disintegrating tablet of aripiprazole prepared by direct compression technique with shortened disintegration time

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recommendations! Published in 2024 at "Pharmaceutical Development and Technology"

DOI: 10.1080/10837450.2024.2301780

Abstract: Abstract Herein, we aimed to formulate a novel oral disintegrating tablet (ODT) of aripiprazole (ARP) capable of rapid disintegration using a direct compression technique. Different ODTs were fabricated with directly compressible excipients, and their disintegration… read more here.

Keywords: disintegration; time; direct compression; oral disintegrating ... See more keywords

The functional attributes of co-processed excipients in direct compression

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recommendations! Published in 2025 at "Pharmaceutical Development and Technology"

DOI: 10.1080/10837450.2025.2584127

Abstract: Abstract The pharmaceutical industry is increasingly adopting co-processed excipients as alternatives to conventional excipients in tablet manufacturing despite certain regulatory challenges. Co-processing of excipients was designed to optimize physical powder properties such as flowability, compressibility,… read more here.

Keywords: functional attributes; excipients direct; processed excipients; direct compression ... See more keywords

Hydroxypropyl-β-Cyclodextrin and β-Cyclodextrin as Tablet Fillers for Direct Compression

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recommendations! Published in 2018 at "AAPS PharmSciTech"

DOI: 10.1208/s12249-018-1115-z

Abstract: Cyclodextrins are cyclic carbohydrates widely used as complexing and non-complexing excipients in drug delivery systems. The purpose of this work was to study the ability of hydroxypropyl-β-cyclodextrin and β-cyclodextrin to act as tablet fillers for… read more here.

Keywords: compression; tablet fillers; fillers direct; cyclodextrin ... See more keywords