A phosphine-based redox method for direct conjugation of disulfides.
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DOI: 10.1039/d2cc04967h
Abstract: Technologies for cysteine disulfide detection and conjugation are pivotal to understanding protein functions and developing disulfide-derived therapeutic agents. Currently, disulfide modification requires reductive cleavage prior to functionalization, posing challenges to differentiating disulfides from free thiols.… read more here.
Keywords: based redox; direct conjugation; method; conjugation ... See more keywords