Designer α1,6-Fucosidase Mutants Enable Direct Core Fucosylation of Intact N-Glycopeptides and N-Glycoproteins.
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DOI: 10.1021/jacs.7b07906
Abstract: Core fucosylation of N-glycoproteins plays a crucial role in modulating the biological functions of glycoproteins. Yet, the synthesis of structurally well-defined, core-fucosylated glycoproteins remains a challenging task due to the complexity in multistep chemical synthesis… read more here.
Keywords: core fucosylation; direct core; glycopeptides glycoproteins; fucosylation intact ... See more keywords