Direct (het)arylation of [1,2,4]triazolo[1,5-a]pyrimidines: Both eliminative and oxidative pathways
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DOI: 10.1016/j.tet.2017.07.042
Abstract: (Hetero)arylation of [1,2,4]triazolo[1,5-a]pyrimidine through the direct nucleophilic CH functionalization of the C-7 and C-5 positions has been implemented. The regioselective addition of a (het)aryl magnesium bromide to C-7 of 6-bromo-[1,2,4]triazolo[1,5-a]pyrimidine, followed by eliminative aromatization of… read more here.
Keywords: arylation triazolo; triazolo; direct het; het arylation ... See more keywords