In silico evidence of direct interaction between statins and β‐amyloid
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27761
Abstract: Aggregation of amyloid‐β (Aβ) peptides represents a crucial step in the pathogenesis of Alzheimer disease (AD). Compelling evidence from preclinical studies has established that statins may reduce amyloidogenesis and Aβ‐mediated neurodegeneration, supporting a potential role… read more here.
Keywords: evidence direct; interaction statins; silico evidence; direct interaction ... See more keywords
ICAM‐1‐mediated osteoblast‐T lymphocyte direct interaction increases mineralization through TGF‐β1 suppression
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30939
Abstract: Modulation of osteoblast functions by T lymphocytes is important in inflammation‐associated mineralized tissue diseases. The study aimed to determine whether direct interaction between these two cell types affects osteoblast functions and mineralization. The results showed… read more here.
Keywords: cell; contact; microscopy; direct interaction ... See more keywords
A direct interaction between two Restless Legs Syndrome predisposing genes: MEIS1 and SKOR1
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30665-6
Abstract: Restless Legs syndrome (RLS) is a common sleep disorder for which the genetic contribution remains poorly explained. In 2007, the first large scale genome wide association study (GWAS) identified three genomic regions associated with RLS.… read more here.
Keywords: meis1 skor1; direct interaction; legs syndrome; restless legs ... See more keywords
Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213437120
Abstract: ABCG2 is an ATP-binding cassette (ABC) transporter that extrudes a wide range of xenobiotics and drugs from the cell and contributes to multidrug resistance in cancer cells. Following our recent structural characterization of topotecan-bound ABCG2,… read more here.
Keywords: differential dynamics; transporter; dynamics direct; direct interaction ... See more keywords
Investigating bitumen’s direct interaction with Tetradecane as potential phase change material for low temperature applications
Sign Up to like & getrecommendations! Published in 2019 at "Road Materials and Pavement Design"
DOI: 10.1080/14680629.2019.1601127
Abstract: Temperature is significantly influencing the behaviour of asphalt road surfaces. In case of cooling, asphalt pavements become stiffer eventually reaching a brittle state at which thermal cracking may occur. Phase change materials (PCM) respond to… read more here.
Keywords: tetradecane; temperature; phase change; direct interaction ... See more keywords
ZNF212 promotes genomic integrity through direct interaction with TRAIP
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1226
Abstract: Abstract TRAIP is a key factor involved in the DNA damage response (DDR), homologous recombination (HR) and DNA interstrand crosslink (ICL) repair. However, the exact functions of TRAIP in these processes in mammalian cells are… read more here.
Keywords: interaction traip; direct interaction; znf212; traip ... See more keywords
Direct Interaction between N-Acetylcysteine and Cytotoxic Electrophile—An Overlooked In Vitro Mechanism of Protection
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11081485
Abstract: In laboratory experiments, many electrophilic cytotoxic agents induce cell death accompanied by reactive oxygen species (ROS) production and/or by glutathione (GSH) depletion. Not surprisingly, millimolar concentrations of N-acetylcysteine (NAC), which is used as a universal… read more here.
Keywords: gsh; cytotoxic; nac; direct interaction ... See more keywords