Ultraefficient extracellular vesicle–guided direct reprogramming of fibroblasts into functional cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abj6621
Abstract: Direct lineage conversion holds great promise in the regenerative medicine field for restoring damaged tissues using functionally engineered counterparts. However, current methods of direct lineage conversion, even those using virus-mediated transgenic expression of tumorigenic factors,… read more here.
Keywords: extracellular vesicle; direct lineage; lineage conversion; vesicle guided ... See more keywords
Efficient Direct Lineage Reprogramming of Fibroblasts into Induced Cardiomyocytes Using Nanotopographical Cues.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2017.2347
Abstract: Induced cardiomyocytes (iCMs) generated via direct lineage reprogramming offer a novel therapeutic target for the study and treatment of cardiac diseases. However, the efficiency of iCM generation is significantly low for therapeutic applications. Here, we… read more here.
Keywords: direct lineage; induced cardiomyocytes; lineage reprogramming; reprogramming fibroblasts ... See more keywords