Asymmetric organocatalytic direct Mannich reaction of acetylacetone and isatin derived ketimines: Low catalyst loading in chiral cinchona-squaramides
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DOI: 10.1016/j.tetlet.2017.12.081
Abstract: Abstract A highly enantioselective synthesis of 3-amino-2-oxindoles by direct Mannich reaction between acetylacetone and N-carbamoyl isatin ketimine has been described herein. Corresponding chiral adducts were obtained in high yields (up to 98%) and with excellent… read more here.
Keywords: reaction acetylacetone; catalyst loading; mannich reaction; direct mannich ... See more keywords