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Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo.

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0 Published in 2017 at "Cancer cell"

DOI: 10.1016/j.ccell.2017.03.003

Abstract: The potassium channel Kv1.3 is highly expressed in the mitochondria of various cancerous cells. Here we show that direct inhibition of Kv1.3 using two mitochondria-targeted inhibitors alters mitochondrial function and leads to reactive oxygen species… read more here.

Keywords: cells vivo; tumor cells; pharmacological targeting; targeting mitochondrial ... See more keywords