Hepatocyte‐like cells generated by direct reprogramming from murine somatic cells can repopulate decellularized livers
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26784
Abstract: Direct reprogramming represents an easy technique to generate induced hepatocytes (iHeps) from somatic cells. However, current protocols are accompanied by several drawbacks as iHeps are heterogenous and lack fully mature phenotypes of primary hepatocytes. Here,… read more here.
Keywords: hepatocyte like; like cells; repopulate decellularized; direct reprogramming ... See more keywords
Dendritic cells generated from induced pluripotent stem cells and by direct reprogramming of somatic cells
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149550
Abstract: Novel and exciting avenues allow generating dendritic cells (DC) by reprogramming of somatic cells. DC are obtained from induced pluripotent stem cells (iPS cells), referred to as ipDC, and by direct reprogramming of cells toward… read more here.
Keywords: pluripotent stem; direct reprogramming; somatic cells; reprogramming somatic ... See more keywords
Direct reprogramming of terminally differentiated cells into neurons: A novel and promising strategy for Alzheimer's disease treatment
Sign Up to like & getrecommendations! Published in 2020 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2019.109820
Abstract: Glial activation is a common pathological process of the central nervous system (CNS) in disorders such as Alzheimer's disease (AD). Several approaches have been used to reduce the number of activated astrocytes and microglia in… read more here.
Keywords: alzheimer disease; cells neurons; direct reprogramming; terminally differentiated ... See more keywords
In vivo direct reprogramming of glial linage to mature neurons after cerebral ischemia
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47482-0
Abstract: The therapeutic effect of in vivo direct reprogramming on ischemic stroke has not been evaluated. In the present study, a retroviral solution (1.5–2.0 × 107 /ul) of mock pMX-GFP (n = 13) or pMX-Ascl1/Sox2/NeuroD1 (ASN) (n = 14) was directly injected… read more here.
Keywords: glial linage; reprogramming glial; cerebral ischemia; direct reprogramming ... See more keywords
Chemical compound-based direct reprogramming for future clinical applications
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20171650
Abstract: Recent studies have revealed that a combination of chemical compounds enables direct reprogramming from one somatic cell type into another without the use of transgenes by regulating cellular signaling pathways and epigenetic modifications. The generation… read more here.
Keywords: cell; direct reprogramming; chemical compound; future clinical ... See more keywords
Efficiency Comparison of Direct Reprogramming CD34+ Cells into Cardiomyocytes Using Cardiomyocyte Differentiation Medium vs MicroRNA-1.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular reprogramming"
DOI: 10.1089/cell.2021.0075
Abstract: The development of a direct reprogramming method to provide cell availability for regenerative therapy has led to a lot of studies. However, the search for appropriate cell sources and methods is still being carried out… read more here.
Keywords: cardiomyocyte differentiation; direct reprogramming; cd34 cells; differentiation medium ... See more keywords
Direct Reprogramming of Different Cell Lineages into Pancreatic β-Like Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular reprogramming"
DOI: 10.1089/cell.2022.0048
Abstract: One major goal of regenerative medicine is the production of pancreatic endocrine islets to treat insulin-dependent diabetic patients. Among the different methods developed to achieve this goal, a particularly promising approach is direct lineage reprogramming,… read more here.
Keywords: reprogramming different; different cell; direct reprogramming; like cells ... See more keywords
TRANSDIRE: data-driven direct reprogramming by a pioneer factor-guided trans-omics approach
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac209
Abstract: MOTIVATION Direct reprogramming involves the direct conversion of fully differentiated mature cell types into various other cell types while bypassing an intermediate pluripotent state (e.g., induced pluripotent stem cells). Cell differentiation by direct reprogramming is… read more here.
Keywords: trans omics; cell types; pioneer; direct reprogramming ... See more keywords
Probing cell identity hierarchies by fate titration and collision during direct reprogramming
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Systems Biology"
DOI: 10.15252/msb.202211129
Abstract: Despite the therapeutic promise of direct reprogramming, basic principles concerning fate erasure and the mechanisms to resolve cell identity conflicts remain unclear. To tackle these fundamental questions, we established a single‐cell protocol for the simultaneous… read more here.
Keywords: cell; titration; collision; cell identity ... See more keywords
Sonoporation-Mediated Gene Transfection: A Novel Direction for Cell Reprogramming In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.803055
Abstract: Cell reprogramming is of great significance to biomedical science, especially in regenerative medicine application. The classical mode called indirect reprogramming is to obtain stem cells or induced pluripotent stem cells (iPSCs) and stimulate them to… read more here.
Keywords: cell reprogramming; direct reprogramming; cell; gene transfection ... See more keywords
Small molecules fail to induce direct reprogramming of adult rat olfactory ensheathing glia to mature neurons
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1110356
Abstract: An approach to generate new neurons after central nervous system injury or disease is direct reprogramming of the individual's own somatic cells into differentiated neurons. This can be achieved either by transduction of viral vectors… read more here.
Keywords: glia mature; adult; direct reprogramming; ensheathing glia ... See more keywords