Copper-Catalyzed Functionalization of Aza-Aromatic Rings with Fluoroalcohols via Direct C(sp2)-H/C(sp3)-H Coupling Reactions.
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DOI: 10.1021/acs.orglett.0c00797
Abstract: An efficient copper-catalyzed direct C(sp2)-H/C(sp3)-H coupling reaction of aza-aromatic rings with fluoroalcohols is developed. A variety of useful building blocks including hydroxyfluoroalkylated aniline, pyrrole, and indole derivatives bearing a quaternary carbon center could be constructed… read more here.
Keywords: sp2 sp3; sp3 coupling; aromatic rings; direct sp2 ... See more keywords
Photoredox-catalyzed direct C(sp2)–H difluoromethylation of enamides or heterocycles with [bis(difluoroacetoxy)iodo]benzene
Sign Up to like & getrecommendations! Published in 2021 at "Organic Chemistry Frontiers"
DOI: 10.1039/d1qo00995h
Abstract: Photoredox-catalyzed direct C(sp2)-H difluoromethylation of enamides is accomplished by using easily accessible [bis(difluoroacetoxy)iodo]benzene as the CF2H source. Diverse (E)-β-difluoromethylated enamides are obtained in moderate to good yields by using this... read more here.
Keywords: bis difluoroacetoxy; sp2 difluoromethylation; direct sp2; difluoromethylation enamides ... See more keywords