Direct C(sp3)-H functionalization of 2-methylazaarenes using 4-substituted-TEMPO
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DOI: 10.1016/j.tetlet.2018.10.014
Abstract: Abstract An efficient and direct C(sp3)-H functionalization of 2-methyl azaarenes with persistent nitroxide radical 4-substituted-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) under neutral conditions has been developed. A broad of 2-methylazaarenes could be reacted with 4-substituted TEMPOs to afford corresponding… read more here.
Keywords: methylazaarenes using; sp3 functionalization; direct sp3; using substituted ... See more keywords
Catalytic Synthesis of N-Heterocycles via Direct C(sp3)–H Amination Using an Air-Stable Iron(III) Species with a Redox-Active Ligand
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DOI: 10.1021/jacs.7b00270
Abstract: Coordination of FeCl3 to the redox-active pyridine–aminophenol ligand NNOH2 in the presence of base and under aerobic conditions generates FeCl2(NNOISQ) (1), featuring high-spin FeIII and an NNOISQ radical ligand. The complex has an overall S… read more here.
Keywords: direct sp3; air stable; redox active; ligand ... See more keywords
tBuOK/DMSO/O2 Catalyzed direct α-C(sp3)-H Alkylation with Styrenes: productive α-amino radical for hydroaminoalkylation
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DOI: 10.1039/d2qo01911f
Abstract: Direct α-C(sp3)-H alkylation of hydroaminoalkylation (HAA) catalyzed by tBuOK/DMSO/O2 from α-aryl benzylamines with styrenes is reported. The reaction has delivered diverse selectively substituted amines and N-heterocycles under mild conditions, showing... read more here.
Keywords: sp3 alkylation; direct sp3; hydroaminoalkylation; tbuok dmso ... See more keywords