Methylation-directed acetylation of histone H3 regulates developmental sensitivity to histone deacetylase inhibition
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DOI: 10.1093/nar/gkab154
Abstract: Abstract Hydroxamate-based lysine deacetylase inhibitors (KDACis) are approved for clinical use against certain cancers. However, intrinsic and acquired resistance presents a major problem. Treatment of cells with hydroxamates such as trichostatin A (TSA) leads to… read more here.
Keywords: acetylation; sensitivity; h3k4me3; directed acetylation ... See more keywords