Methionine‐associated peptide α‐amidation is directed both to the N‐ and the C‐terminal amino acids
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DOI: 10.1002/psc.3429
Abstract: Peptide‐bound methionine may transfer oxidative damage from the thioether side chain to the peptide backbone, catalyzing decomposition in general and α‐amidation in particular. In the present study, we focused on the reactivity and reaction pathways… read more here.
Keywords: amidation; methionine; directed amidation; terminus directed ... See more keywords
Continuous-flow Directed C–H Amidation Reactions Using Immobilized Cp*Rh(III) Catalysts
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DOI: 10.1039/d4gc01747a
Abstract: We report a green, continuous-flow C–H amidation methodology using heterogeneous Cp*Rh(III) catalysts. These catalysts enable halide- and salt-free reactions with excellent activity and durability across diverse substrates, demonstrated by a... read more here.
Keywords: continuous flow; iii catalysts; flow directed; directed amidation ... See more keywords