Progress, applications, and challenges in high-throughput effect-directed analysis for toxicity driver identification — is it time for HT-EDA?
Sign Up to like & getrecommendations! Published in 2024 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-024-05424-4
Abstract: The rapid increase in the production and global use of chemicals and their mixtures has raised concerns about their potential impact on human and environmental health. With advances in analytical techniques, in particular, high-resolution mass… read more here.
Keywords: high throughput; effect directed; directed analysis; eda ... See more keywords
Integrating Effect-Directed Analysis and Chemically Indicative Mass Spectral Fragmentation to Screen for Toxic Organophosphorus Compounds.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04842
Abstract: Analytical chemists are often challenged to screen for bioactive compounds in complex matrices, sometimes without a priori knowledge of the exact compound of interest. Therefore, "flagging" techniques, highlighting common characteristics of bioactive compounds, are highly… read more here.
Keywords: integrating effect; directed analysis; screen; organophosphorus ... See more keywords
High-Performance Data Processing Workflow Incorporating Effect-Directed Analysis for Feature Prioritization in Suspect and Nontarget Screening
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Science & Technology"
DOI: 10.1021/acs.est.1c04168
Abstract: Effect-directed analysis (EDA) aims at the detection of bioactive chemicals of emerging concern (CECs) by combining toxicity testing and high-resolution mass spectrometry (HRMS). However, consolidation of toxicological and chemical analysis techniques to identify bioactive CECs… read more here.
Keywords: high performance; analysis; workflow incorporating; directed analysis ... See more keywords
Identification of the estrogen-active compounds via integrating effect-directed analysis and non-target screening in soils of the northeastern China
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DOI: 10.1186/s12302-024-00885-x
Abstract: Background The gaps between estrogenic effect and its effect-active compounds exist frequently due to a large number of compounds that have been reported to induce this effect and the occurrence of pollutants in environments as… read more here.
Keywords: effect directed; effect; estrogen active; directed analysis ... See more keywords
Suspect Screening of Chemicals in Hospital Wastewaters Using Effect-Directed Analysis Approach as Prioritization Strategy
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031212
Abstract: The increasing number of contaminants in the environment has pushed water monitoring programs to find out the most hazardous known and unknown chemicals in the environment. Sample treatment-simplification methods and non-target screening approaches can help… read more here.
Keywords: directed analysis; toxic fractions; analysis; effect directed ... See more keywords