NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro.
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DOI: 10.1111/jnc.15778
Abstract: Alzheimer's disease (AD) is associated with the cerebral deposition of Amyloid-β (Aβ) peptide, which leads to NLRP3 inflammasome activation and subsequent release of interleukin-1β (IL-1β) and interleukin-18 (IL-18). NLRP3 reduction has been found to increase… read more here.
Keywords: nlrp3 directed; directed antisense; antisense oligonucleotides; primary murine ... See more keywords