A Selective SARS-CoV-2 Host-Directed Antiviral Targeting Stress Response to Reactive Oxygen Species
Sign Up to like & getrecommendations! Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c01243
Abstract: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) catalyzed the development of vaccines and antivirals. Clinically approved drugs against SARS-CoV-2 target the virus directly, which makes them susceptible to viral mutations, which in… read more here.
Keywords: reactive oxygen; host directed; directed antiviral; oxygen species ... See more keywords
Host-Directed Antiviral Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Microbiology Reviews"
DOI: 10.1128/cmr.00168-19
Abstract: Antiviral drugs have traditionally been developed by directly targeting essential viral components. However, this strategy often fails due to the rapid generation of drug-resistant viruses. Recent genome-wide approaches, such as those employing small interfering RNA… read more here.
Keywords: directed antiviral; drug resistant; virus; host ... See more keywords