Neochrysosporazines: Precursor-Directed Biosynthesis Defines a Marine-Derived Fungal Natural Product P-Glycoprotein Inhibitory Pharmacophore.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01989.s001
Abstract: Upregulation of ATP binding cassette (ABC) transporter efflux pumps (i.e. P-glycoprotein, P-gp) can impart multidrug resistance, rendering many chemotherapeutics ineffective and seriously limiting treatment regimes. While ABC transporters remain an attractive target for therapeutic intervention,… read more here.
Keywords: directed biosynthesis; inhibitory pharmacophore; precursor directed; marine derived ... See more keywords
Precursor-Directed Biosynthesis and Fluorescence Labeling of Clickable Microcystins.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.0c00251
Abstract: Microcystins, cyclic nonribosomal heptapeptides, are the most well-known cyanobacterial toxins. They are exceptionally well studied, but open questions remain concerning their physiological role for the producing microorganism or their suitability as lead compounds for anticancer… read more here.
Keywords: clickable microcystins; precursor directed; biosynthesis fluorescence; fluorescence labeling ... See more keywords
Directed Biosynthesis of Iso-aclacinomycins with Improved Anticancer Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b04069
Abstract: A four-enzyme catalyzed hydroxy regioisomerization of anthracycline was integrated into the biosynthetic pathway of aclacinomycin A (ALM-A), to generate a series of iso-ALMs via directed combinatorial biosynthesis combined with precursor-directed mutasynthesis. Most of the newly… read more here.
Keywords: biosynthesis iso; biosynthesis; iso; iso alms ... See more keywords
Directed Biosynthesis of Mitragynine Stereoisomers
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13644
Abstract: Mitragyna speciosa (“Kratom”) is used as a natural remedy for pain and management of opioid dependence. The pharmacological properties of Kratom have been linked to a complex mixture of monoterpene indole alkaloids, most notably mitragynine.… read more here.
Keywords: biosynthesis mitragynine; mitragynine stereoisomers; mitragynine; directed biosynthesis ... See more keywords
Precursor-Directed Biosynthesis of Aminofulvenes: New Chalanilines from Endophytic Fungus Chalara sp.
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DOI: 10.3390/molecules26154418
Abstract: The plant endophyte Chalara sp. is able to biotransform the epigenetic modifier vorinostat to form unique, aniline-containing polyketides named chalanilines. Here, we sought to expand the chemical diversity of chalaniline A-type molecules by changing the… read more here.
Keywords: biosynthesis aminofulvenes; precursor directed; precursor; chalara ... See more keywords