Mechanism-Based Design of an Amide-Directed Ni-Catalyzed Arylboration of Cyclopentene Derivatives.
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DOI: 10.1021/acs.orglett.0c04208
Abstract: A method for amide-directed Ni-catalyzed diastereoselective arylboration of cyclopentenes is disclosed. The reaction allows for the synthesis of sterically congested cyclopentane scaffolds that contain an easily derivatized boronic ester and amide functional handles. The nature… read more here.
Keywords: amide directed; arylboration; design amide; based design ... See more keywords
Hydroxyl-Directed Ru(II)-Catalyzed Synthesis of Fused Dihydrofurans Using 1,4-Dioxane and Sulfoxonium Ylides as Annulating Agents.
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DOI: 10.1021/acs.orglett.2c04068
Abstract: An unprecedented annulation reaction is developed for the synthesis of dihydrofuran-fused compounds. In this Ru-catalyzed hydroxyl-group-directed reaction, easily affordable sulfoxonium ylides and 1,4-dioxane were used as the annulating partners. This is the first example of… read more here.
Keywords: directed catalyzed; dioxane; synthesis; hydroxyl directed ... See more keywords
Acylsilane Directed Rh-Catalyzed Arene C-H Alkylation with Maleimides and Visible-Light-Induced Siloxycarbene-Amide Cyclization: [3 + 2] Carbo-Annulation in Ru Catalysis.
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DOI: 10.1021/acs.orglett.3c00487
Abstract: We herein demonstrate the acylsilane-directed Rh-catalyzed arene C-H bond alkylation with maleimides. The resulting derivatives were utilized in visible-light-induced intramolecular siloxycarbene-amide cyclization for the synthesis of new tricyclic γ-lactams. In parallel, we also harnessed the… read more here.
Keywords: directed catalyzed; light induced; catalyzed arene; acylsilane directed ... See more keywords