Site-Directed Chemical Probing to map transient RNA/protein interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2016.12.011
Abstract: RNA-protein interactions are at the bases of many biological processes, forming either tight and stable functional ribonucleoprotein (RNP) complexes (i.e. the ribosome) or transitory ones, such as the complexes involving RNA chaperone proteins. To localize… read more here.
Keywords: protein; directed chemical; protein interactions; rna ... See more keywords
Peptidoglycan-Directed Chemical Ligation for Selective Inhibition on Gram-Positive Bacteria
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c06964
Abstract: Microbicides with distinct antibacterial mechanisms show potential to combat multi-drug resistance bacteria. We herein report peptidoglycan-directed chemical ligation (PGCL) between alkyne-bearing vancomycin and an azide-tagged cationic polymer. The former binds peptidoglycan and inhibits peptidoglycan crosslinking,… read more here.
Keywords: chemical ligation; gram; directed chemical; gram positive ... See more keywords
Halogen-directed chemical sialylation: pseudo-stereodivergent access to marine ganglioside epitopes†‡
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc01219j
Abstract: Sialic acids are conspicuous structural components of the complex gangliosides that regulate cellular processes. Their importance in molecular recognition manifests itself in drug design (e.g. Tamiflu®) and continues to stimulate the development of effective chemical… read more here.
Keywords: directed chemical; chemical sialylation; pseudo stereodivergent; halogen directed ... See more keywords
Effect-Directed, Chemical and Taxonomic Profiling of Peppermint Proprietary Varieties and Corresponding Leaf Extracts
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12020476
Abstract: During the development of novel, standardized peppermint extracts targeting functional applications, it is critical to adequately characterize raw material plant sources to assure quality and consistency of the end-product. This study aimed to characterize existing… read more here.
Keywords: peppermint; directed chemical; chemical taxonomic; profiling ... See more keywords