Copper-Catalyzed, N-Directed Distal C(sp3)-H Functionalization toward Azepanes.
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DOI: 10.1021/acs.orglett.2c03135
Abstract: We herein report a copper-catalyzed formal [5 + 2] aza-annulation of N-fluorosulfonamides and 1,3-dienes/1,3-enynes for synthesis of structurally diverse alkene/alkyne-containing azepanes. The reaction features selective functionalization of distal unactivated C(sp3)-H bonds and a broad substrate… read more here.
Keywords: distal sp3; catalyzed directed; directed distal; sp3 functionalization ... See more keywords