Virus-directed enzyme prodrug therapy and the assessment of the cytotoxic impact of some benzimidazole derivatives
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DOI: 10.1177/1010428317713675
Abstract: Virus-directed enzyme prodrug therapy is one of the major strategy of increasing cytotoxicity of bioreductive agents. This research intended to examine new selected benzimidazole derivatives as a substrate for nitroreductase, the enzyme involved in nitroreduction… read more here.
Keywords: virus directed; enzyme prodrug; prodrug therapy; directed enzyme ... See more keywords
The YfkO Nitroreductase from Bacillus Licheniformis on Gold-Coated Superparamagnetic Nanoparticles: Towards a Novel Directed Enzyme Prodrug Therapy Approach
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DOI: 10.3390/pharmaceutics13040517
Abstract: The bacterial nitroreductase NfnB has been the focus of a great deal of research for its use in directed enzyme prodrug therapy in combination with the nitroreductase prodrug CB1954 with this combination of enzyme and… read more here.
Keywords: yfko nitroreductase; enzyme prodrug; nitroreductase bacillus; prodrug therapy ... See more keywords