Cobalt(II)-Catalyzed Directed C-H Functionalization/[3+2] Annulation of N-Arylguanidines with Alkynes.
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DOI: 10.1021/acs.orglett.2c02503
Abstract: A family of N,N'-diaryl-N″-(quinolin-8-yl)guanidines were prepared by two methods, and these guanidines were subjected to Co(II)-catalyzed C-H functionalization/annulation with terminal and internal alkynes under mild conditions to afford a family of indole guanidines. Substrates with… read more here.
Keywords: cobalt catalyzed; catalyzed directed; functionalization annulation; directed functionalization ... See more keywords
Racemic Total Synthesis of Elmonin and Pratenone A, from Streptomyces, Using a Common Intermediate Prepared by peri-Directed C–H Functionalization
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DOI: 10.1021/acs.orglett.2c03449
Abstract: The first total synthesis of elmonin and pratenone A, two complex rearranged angucyclinones from Streptomyces, is reported. Using peri-directed C–H functionalization, the key naphthalene fragment present in both synthetic targets was efficiently prepared. Coupling to… read more here.
Keywords: directed functionalization; elmonin pratenone; total synthesis; peri directed ... See more keywords
Rh(I)-catalysed imine-directed C-H functionalization via the oxidative [3 + 2] cycloaddition of benzylamine derivatives with maleimides.
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DOI: 10.1039/d1cc06622f
Abstract: The Rh(I)-catalysed imine-directed oxidative [3 + 2] cycloaddition of benzylamines with maleimides is reported. A wide range of both benzylamines and maleimides is applicable to the reaction. A one-pot three component strategy using benzylamines, 2-pyridinecarboxaldehyde,… read more here.
Keywords: oxidative cycloaddition; catalysed imine; directed functionalization; imine directed ... See more keywords