AI-directed gene fusing prolongs the evolutionary half-life of synthetic gene circuits
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1101/2025.02.10.637495
Abstract: Evolutionary instability is a persistent challenge in synthetic biology, often leading to the loss of heterologous gene expression over time. Here, we present STABLES, a novel gene fusion strategy that links a gene of interest… read more here.
Keywords: directed gene; fusing prolongs; gene fusing; biology ... See more keywords
Defenestrated endothelium delays liver-directed gene transfer in hemophilia A mice.
Sign Up to like & getrecommendations! Published in 2022 at "Blood advances"
DOI: 10.1182/bloodadvances.2021006388
Abstract: Hemophilia A is an inherited bleeding disorder caused by defective or deficient coagulation factor-VIII (FVIII) activity. Until recently, the only treatment for prevention of bleeding involved intravenous administration of FVIII. Gene therapy with adeno associated… read more here.
Keywords: mice; directed gene; gene; liver directed ... See more keywords