Precursor-Directed Generation of Indolocarbazoles with Topoisomerase IIα Inhibitory Activity
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DOI: 10.3390/md16050168
Abstract: One new indolocarbazole, 3-hydroxy-K252d (3), together with the recently reported 3-hydroxyholyrine A (1) and 3′-N-acetyl-3-hydroxyholyrine A (2), were obtained by feeding a culture of the marine-derived Streptomyces strain OUCMDZ-3118 with 5-hydroxy-l-tryptophan. Their structures were elucidated… read more here.
Keywords: precursor directed; directed generation; topoisomerase inhibitory; indolocarbazoles topoisomerase ... See more keywords