CD19‐directed immunotherapy use in KMT2A‐rearranged acute leukemia: A case report and literature review of increased lymphoid to myeloid lineage switch
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26713
Abstract: To the Editor: Acute lymphoblastic leukemia (ALL) bearing the KMT2Arearrangement is a high-risk genomic subgroup, characterized by chemotherapy-resistance and a propensity for rapid relapse with reported 5-year overall survival of less than 20%. Unique in… read more here.
Keywords: kmt2a rearranged; directed immunotherapy; leukemia; cd19 directed ... See more keywords
Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation
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DOI: 10.1007/s11684-018-0665-5
Abstract: The efficacy of minimal residual disease (MRD)-directed immunotherapy, including interferon-α (IFN- α) treatment and chemotherapy plus granulocyte colony-stimulating factor-primed donor leukocyte infusion (chemo-DLI), was investigated in patients with high-risk myelodysplastic syndrome (MDS) who were MRD-positive… read more here.
Keywords: risk; minimal residual; high risk; residual disease ... See more keywords
Host-directed immunotherapy to fight infectious diseases
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DOI: 10.1097/mop.0000000000001176
Abstract: Purpose of review This review provides readers with examples of refractory infections due to inborn errors of immunity, highlighting how they may be successfully treated by deducing and targeting the underlying immunodeficiency. Recent findings The… read more here.
Keywords: immunotherapy fight; host directed; inborn errors; directed immunotherapy ... See more keywords